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oai:repisalud.isciii.es:20.500.12105/64462025-06-19T16:02:08Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19613

00925njm 22002777a 4500 dc Lorenz, Matthias W author Gao, Lu author Ziegelbauer, Kathrin author Norata, Giuseppe Danilo author Empana, Jean Philippe author Schmidtmann, Irene author Lin, Hung-Ju author McLachlan, Stela author Bokemark, Lena author Ronkainen, Kimmo author Amato, Mauro author Schminke, Ulf author Srinivasan, Sathanur R author Lind, Lars author Okazaki, Shuhei author Stehouwer, Coen D A author Willeit, Peter author Polak, Joseph F author Steinmetz, Helmuth author Sander, Dirk author Poppert, Holger author Desvarieux, Moise author Ikram, M Arfan author Johnsen, Stein Harald author Staub, Daniel author Sirtori, Cesare R author Iglseder, Bernhard author Beloqui, Oscar author Engström, Gunnar author Friera, Alfonso author Rozza, Francesco author Xie, Wuxiang author Parraga, Grace author Grigore, Liliana author Plichart, Matthieu author Blankenberg, Stefan author Su, Ta-Chen author Schmidt, Caroline author Tuomainen, Tomi-Pekka author Veglia, Fabrizio author Völzke, Henry author Nijpels, Giel author Willeit, Johann author Sacco, Ralph L author Franco, Oscar H author Uthoff, Heiko author Hedblad, Bo author Suarez, Carmen author Izzo, Raffaele author Zhao, Dong author Wannarong, Thapat author Catapano, Alberico author Ducimetiere, Pierre author Espinola-Klein, Christine author Chien, Kuo-Liong author Price, Jackie F author Bergström, Göran author Kauhanen, Jussi author Tremoli, Elena author Dörr, Marcus author Berenson, Gerald author Kitagawa, Kazuo author Dekker, Jacqueline M author Kiechl, Stefan author Sitzer, Matthias author Bickel, Horst author Rundek, Tatjana author Hofman, Albert author Mathiesen, Ellisiv B author Castelnuovo, Samuela author Landecho, Manuel F author Rosvall, Maria author Gabriel-Sanchez, Rafael author de Luca, Nicola author Liu, Jing author Baldassarre, Damiano author Kavousi, Maryam author de Groot, Eric author Bots, Michiel L author Yanez, David N author Thompson, Simon G author 2018 AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals. PLoS One. 2018 Apr 12;13(4):e0191172 10.1371/journal.pone.0191172 1932-6203 1932-6203 PloS one 29649236 http://hdl.handle.net/20.500.12105/6446 Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration