2026-08-29T13:16:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/60972024-09-21T16:00:17Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Peinado, Héctor
author
Zhang, Haiying
author
Matei, Irina R
author
Costa-Silva, Bruno
author
Hoshino, Ayuko
author
Rodrigues, Goncalo
author
Psaila, Bethan
author
Kaplan, Rosandra N
author
Bromberg, Jacqueline F
author
Kang, Yibin
author
Bissell, Mina J
author
Cox, Thomas R
author
Giaccia, Amato J
author
Erler, Janine T
author
Hiratsuka, Sachie
author
Ghajar, Cyrus M
author
Lyden, David
2018-06-01T11:12:54Z
2018-06-01T11:12:54Z
2017-05
Nat Rev Cancer.2018; 17(5):302-317.
10.1038/nrc.2017.6
1474-1768
1474-175X
Nature reviews. Cancer
28303905
http://hdl.handle.net/20.500.12105/6097
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.
eng
BREAST-CANCER METASTASIS
MONOCYTE CHEMOATTRACTANT PROTEIN-1
TUMOR BARRIER PERMEABILITY
GROWTH-FACTOR RECEPTOR-1
C CHEMOKINE RECEPTOR-5
COLLAGEN CROSS-LINKING
SENTINEL LYMPH-NODES
E-SELECTIN LIGAND-1
PREMETASTATIC NICHE;
CANCER PROSTATE
Pre-metastatic niches: organ-specific homes for metastases
journal article
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URL
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Pre-metastaticNichesOrganSpecific_2018.pdf.txt