2026-08-29T13:17:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/60972024-09-21T16:00:17Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Peinado, Héctor author Zhang, Haiying author Matei, Irina R author Costa-Silva, Bruno author Hoshino, Ayuko author Rodrigues, Goncalo author Psaila, Bethan author Kaplan, Rosandra N author Bromberg, Jacqueline F author Kang, Yibin author Bissell, Mina J author Cox, Thomas R author Giaccia, Amato J author Erler, Janine T author Hiratsuka, Sachie author Ghajar, Cyrus M author Lyden, David author 2017-05 It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche. Nat Rev Cancer.2018; 17(5):302-317. 10.1038/nrc.2017.6 1474-1768 1474-175X Nature reviews. Cancer 28303905 http://hdl.handle.net/20.500.12105/6097 BREAST-CANCER METASTASIS MONOCYTE CHEMOATTRACTANT PROTEIN-1 TUMOR BARRIER PERMEABILITY GROWTH-FACTOR RECEPTOR-1 C CHEMOKINE RECEPTOR-5 COLLAGEN CROSS-LINKING SENTINEL LYMPH-NODES E-SELECTIN LIGAND-1 PREMETASTATIC NICHE; CANCER PROSTATE Pre-metastatic niches: organ-specific homes for metastases