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oai:repisalud.isciii.es:20.500.12105/57832025-05-05T11:40:41Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16964col_20.500.12105_16981col_20.500.12105_16983

00925njm 22002777a 4500 dc Alonso-Molero, Jéssica author González-Donquiles, Carmen author Palazuelos, Camilo author Fernández-Villa, Tania author Ramos, Elena author Pollan-Santamaria, Marina author Aragones, Nuria author Llorca, Javier author Henar Alonso, M. author Tardón, Adonina author Amiano, Pilar author Jimenez-Moleon, Jose J. author Peiró Pérez, Rosana author Capelo, Rocío author Molina, Antonio J author Acebo, Ines Gomez author Guevara, Marcela author Perez-Gomez, Beatriz author Lope Carvajal, Virginia author Huerta, José María author Castaño-Vinyals, Gemma author Kogevinas, Manolis author Moreno, Victor author Martín, Vicente author 2017-10-30 BACKGROUND: The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. METHODS: We examined 1087 cases of colorectal cancer and 2409 population controls with available DNA samples from the MCC-Spain study, 2008-2012. Descriptive statistical analyses, and multivariate logistic mixed models were performed. The potential synergistic effect of rs4939827 and the Mediterranean diet pattern was evaluated with logistic regression in different strata of of adherence to the Mediterranean diet and the genotype. RESULTS: High adherence to Mediterrenean diet was statistically significantly associated with colorectal cancer risk. A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827. Although the decreased risk for the CC genotype was slightly more pronounced in subjects with high adherence to Mediterrenean diet, there was no statistically significant synergistic effect between genotype CC and adherence to the Mediterranean dietary pattern factors. CONCLUSION: The SMAD7 gene and specifically the allele C could be protective for colorectal cancer. An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC risk. Findings form this study indicate that high adherence to Mediterranean diet pattern has a protective role for CRC cancer probably involving the Tumor Growth Factor- β pathway in this cancer. BMC Med Genet. 2017; 18(1):122 10.1186/s12881-017-0485-5 1471-2350 1471-2350 BMC Medical Genetics 29084532 http://hdl.handle.net/20.500.12105/5783 Colorectal cancer Gene-environment Mediterranean diet SMAD7 rs4939827 The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis