2026-04-30T09:02:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/57732024-09-27T20:59:44Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gonzalez Portal, Maria Eugenia
funder
Instituto de Salud Carlos III
2018-03-21T11:13:23Z
2018-03-21T11:13:23Z
2015-08-04
Viruses. 2015;7(8):4352-68
10.3390/v7082824
1999-4915
1999-4915
Viruses
26247957
http://hdl.handle.net/20.500.12105/5773
Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. Notwithstanding the high variability of its amino acid sequence, the functionality of Vpu is well conserved in pandemic virus isolates. This review outlines our current knowledge on the interactions of Vpu with the host cell. The regulation of cellular physiology by Vpu and the validity of this viroporin as a therapeutic target are also discussed.
eng
HIV-1
Viroporin
Vpu
Antiretroviral target
Ion transport
Membrane permeability
Membrane pore
Protein trafficking
Vpu Protein: The Viroporin Encoded by HIV-1
journal article
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VpuProteinTheViroporin_2015.pdf.txt
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VpuProteinTheViroporin_2015.pdf.txt
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VpuProteinTheViroporin_2015.pdf.txt
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VpuProteinTheViroporin_2015.pdf.txt