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oai:repisalud.isciii.es:20.500.12105/57732024-09-27T20:59:44Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Gonzalez Portal, Maria Eugenia author 2015-08-04 Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. Notwithstanding the high variability of its amino acid sequence, the functionality of Vpu is well conserved in pandemic virus isolates. This review outlines our current knowledge on the interactions of Vpu with the host cell. The regulation of cellular physiology by Vpu and the validity of this viroporin as a therapeutic target are also discussed. Viruses. 2015;7(8):4352-68 10.3390/v7082824 1999-4915 1999-4915 Viruses 26247957 http://hdl.handle.net/20.500.12105/5773 HIV-1 Viroporin Vpu Antiretroviral target Ion transport Membrane permeability Membrane pore Protein trafficking Vpu Protein: The Viroporin Encoded by HIV-1