2026-04-29T07:22:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/57672024-09-27T21:40:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gonzalez Portal, Maria Eugenia
funder
Instituto de Salud Carlos III
2018-03-20T12:33:06Z
2018-03-20T12:33:06Z
2017-01-10
Int J Mol Sci. 2017;18(1). pii: E126.
1422-0067
http://hdl.handle.net/20.500.12105/5767
28075409
10.3390/ijms18010126
1422-0067
International journal of molecular sciences
The human immunodeficiency virus type 1 (HIV-1) Vpr protein is an attractive target for antiretroviral drug development. The conservation both of the structure along virus evolution and the amino acid sequence in viral isolates from patients underlines the importance of Vpr for the establishment and progression of HIV-1 disease. While its contribution to virus replication in dividing and non-dividing cells and to the pathogenesis of HIV-1 in many different cell types, both extracellular and intracellular forms, have been extensively studied, its precise mechanism of action nevertheless remains enigmatic. The present review discusses how the apparently multifaceted interplay between Vpr and host cells may be due to the impairment of basic metabolic pathways. Vpr protein modifies host cell energy metabolism, oxidative status, and proteasome function, all of which are likely conditioned by the concentration and multimerization of the protein. The characterization of Vpr domains along with new laboratory tools for the assessment of their function has become increasingly relevant in recent years. With these advances, it is conceivable that drug discovery efforts involving Vpr-targeted antiretrovirals will experience substantial growth in the coming years.
eng
Vpr protein
Antiretroviral target
Cellular metabolism
Mechanism of action
Pathogenesis
The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention
journal article
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TheHIV1VprProtein_2017.pdf
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TheHIV1VprProtein_2017.pdf.txt
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TheHIV1VprProtein_2017.pdf.txt