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oai:repisalud.isciii.es:20.500.12105/57482025-04-25T09:23:36Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978

00925njm 22002777a 4500 dc de Miguel-Diez, Javier author Lopez-de-Andres, Ana author Jiménez-García, Rodrigo author Puente-Maestu, Luis author Jimenez-Trujillo, Isabel author Hernandez-Barrera, Valentin author Resino, Salvador author Álvaro-Meca, Alejandro author 2016-11-15 PURPOSE: The aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997-2012). METHODS: A retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection). RESULTS: 1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997-1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004-2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD. CONCLUSIONS: Incidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era. PLoS One. 2016 Nov 15;11(11):e0166421. 10.1371/journal.pone.0166421 1932-6203 1932-6203 PLOS ONE 27846297 http://hdl.handle.net/20.500.12105/5748 Adult Antiretroviral Therapy, Highly Active Antiviral Agents Coinfection Female HIV Infections Hepatitis C, Chronic Hospital Mortality Hospitalization Humans Incidence Male Middle Aged Pulmonary Disease, Chronic Obstructive Retrospective Studies Spain Survival Analysis Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)