2026-04-26T23:19:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/55412024-10-31T11:48:44Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
advisor
Fundación Ramón Areces
advisor
Fundación La Caixa
advisor
Ministerio de Educación (España)
author
Isern, Joan
author
Garcia-Garcia, Andres
author
Martin, Ana M.
author
Arranz, Lorena
author
Martin-Perez, Daniel
author
Torroja, Carlos
author
Sanchez-Cabo, Fatima
author
Mendez-Ferrer, Simon
funder
Fundación Ramón Areces
funder
Fundación La Caixa
funder
Howard Hughes Medical Institute
funder
Ministerio de Economía y Competitividad (España)
2017-12-01T07:37:29Z
2017-12-01T07:37:29Z
2014
Elife. 2014 Sep 25;3:e03696
2050-084X
http://hdl.handle.net/20.500.12105/5541
25255216
10.7554/eLife.03696
ELIFE
Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. Here we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions. Proliferative mesoderm-derived nestin-MSCs participate in fetal skeletogenesis, and lose MSC activity soon after birth. In contrast, quiescent neural-crest-derived nestin(+) cells in the same bones preserve MSC activity, but do not generate fetal chondrocytes. Instead, they differentiate into HSC-niche-forming MSCs, helping to establish the HSC niche by secreting Cxcl12. Perineural migration of these cells to the bone marrow requires the ErbB3 receptor. The neonatal Nestin-GFP(+) PDGFR alpha(-) cell population also contains Schwann-cell precursors, but does not comprise mature Schwann cells. Thus, in the developing bone marrow HSC-niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells, and ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC niche formation.
eng
BONE-MARROW NICHE
PERIPHERAL-NERVES
PROGENITOR CELLS
BLOOD-VESSELS
SCHWANN-CELLS
DIFFERENTIATION
EXPRESSION
OSTEOBLAST
RECEPTOR
ALPHA
The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem-cell-niche function
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Theneuralcrestisasource_2014_supp.docx
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Theneuralcrestisasource_2014.pdf.txt
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Theneuralcrestisasource_2014_supp.docx.txt