2026-07-22T03:36:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/55402024-09-27T07:56:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Villa del Campo, Cristina
author
Claveria, Cristina
author
Sierra, Rocio
author
Torres, Miguel
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación ProCNIC
2017-12-01T07:37:29Z
2017-12-01T07:37:29Z
2014
Cell Rep. 2014; 8(6):1741-51
10.1016/j.celrep.2014.08.005
2211-1247
Cell Reports
25199831
http://hdl.handle.net/20.500.12105/5540
Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardio-myocyte-replacement strategy.
eng
CARDIAC PROGENITOR CELLS
C-MYC
MYOCYTE HYPERTROPHY
CIRCADIAN CLOCK
DNA-SYNTHESIS
IN-VIVO
DROSOPHILA
RECEPTOR
PATHWAY
DEATH
Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
journal article
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CellCompetitionPromotesPhenotypically_2014_supplmat.pdf
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CellCompetitionPromotesPhenotypically_2014.pdf.txt
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