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00925njm 22002777a 4500 dc Villa del Campo, Cristina author Claveria, Cristina author Sierra, Rocio author Torres, Miguel author 2014 Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardio-myocyte-replacement strategy. Cell Rep. 2014; 8(6):1741-51 10.1016/j.celrep.2014.08.005 2211-1247 Cell Reports 25199831 http://hdl.handle.net/20.500.12105/5540 CARDIAC PROGENITOR CELLS C-MYC MYOCYTE HYPERTROPHY CIRCADIAN CLOCK DNA-SYNTHESIS IN-VIVO DROSOPHILA RECEPTOR PATHWAY DEATH Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart