2026-07-23T17:03:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/55242024-09-27T08:02:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Liappas, Georgios
author
Tirma Gonzalez-Mateo, Guadalupe
author
Majano, Pedro
author
Antonio Sanchez-Tomero, Jose
author
Ruiz-Ortega, Marta
author
Rodrigues Diez, Raquel
author
Martin, Pilar
author
Sanchez-Diaz, Raquel
author
Selgas, Rafael
author
Lopez-Cabrera, Manuel
author
Aguilera Peralta, Abelardo
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea
2017-12-01T07:37:27Z
2017-12-01T07:37:27Z
2015
Biomed Res Int. 2015; 2015:416480
10.1155/2015/416480
2314-6141
2314-6133
BioMed Research International
26064907
http://hdl.handle.net/20.500.12105/5524
Fibrosis is a general complication in many diseases. It is the main complication during peritoneal dialysis (PD) treatment, a therapy for renal failure disease. Local inflammation and mesothelial to mesenchymal transition (MMT) are well known key phenomena in peritoneal damage during PD. New data suggest that, in the peritoneal cavity, inflammatory changes may be regulated at least in part by a delicate balance between T helper 17 and regulatory T cells. This paper briefly reviews the implication of the Th17/Tregaxis in fibrotic diseases. Moreover, it compares current evidences described in PD animal experimental models, indicating a loss of Th17/Treg balance (Th17 predominance) leading to peritoneal damage during PD. In addition, considering the new clinical and animal experimental data, new therapeutic strategies to reduce the Th17 response and increase the regulatory T response are proposed. Thus, future goals should be to develop new clinical biomarkers to reverse this immune misbalance and reduce peritoneal fibrosis in PD.
eng
ROR-GAMMA-T
MESENCHYMAL TRANSITION
AUTOIMMUNE ENCEPHALOMYELITIS
MESOTHELIAL CELLS
PULMONARY INFLAMMATION
MOLECULAR-MECHANISMS
IL-6-DEFICIENT MICE
IL-17 EXPRESSION
IMMUNE-RESPONSE
GROWTH-FACTOR
T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage
journal article
URL
https://repisalud.isciii.es/bitstreams/8b748c68-d2b7-4f86-80ef-1083f17be0ef/download
File
MD5
62f0cb525831b1e63282eebbceaee5a3
3892720
application/pdf
THelper17RegulatoryTCel_2015l.pdf
URL
https://repisalud.isciii.es/bitstreams/362ae9b9-00bd-4edc-aced-4d181ce66628/download
File
MD5
02ef08109237e20cae3275878dc56e52
49478
text/plain
THelper17RegulatoryTCel_2015l.pdf.txt