2026-07-23T17:03:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/55242024-09-27T08:02:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Liappas, Georgios author Tirma Gonzalez-Mateo, Guadalupe author Majano, Pedro author Antonio Sanchez-Tomero, Jose author Ruiz-Ortega, Marta author Rodrigues Diez, Raquel author Martin, Pilar author Sanchez-Diaz, Raquel author Selgas, Rafael author Lopez-Cabrera, Manuel author Aguilera Peralta, Abelardo author 2015 Fibrosis is a general complication in many diseases. It is the main complication during peritoneal dialysis (PD) treatment, a therapy for renal failure disease. Local inflammation and mesothelial to mesenchymal transition (MMT) are well known key phenomena in peritoneal damage during PD. New data suggest that, in the peritoneal cavity, inflammatory changes may be regulated at least in part by a delicate balance between T helper 17 and regulatory T cells. This paper briefly reviews the implication of the Th17/Tregaxis in fibrotic diseases. Moreover, it compares current evidences described in PD animal experimental models, indicating a loss of Th17/Treg balance (Th17 predominance) leading to peritoneal damage during PD. In addition, considering the new clinical and animal experimental data, new therapeutic strategies to reduce the Th17 response and increase the regulatory T response are proposed. Thus, future goals should be to develop new clinical biomarkers to reverse this immune misbalance and reduce peritoneal fibrosis in PD. Biomed Res Int. 2015; 2015:416480 10.1155/2015/416480 2314-6141 2314-6133 BioMed Research International 26064907 http://hdl.handle.net/20.500.12105/5524 ROR-GAMMA-T MESENCHYMAL TRANSITION AUTOIMMUNE ENCEPHALOMYELITIS MESOTHELIAL CELLS PULMONARY INFLAMMATION MOLECULAR-MECHANISMS IL-6-DEFICIENT MICE IL-17 EXPRESSION IMMUNE-RESPONSE GROWTH-FACTOR T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage