2026-06-14T03:44:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/55202024-09-27T08:03:18Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Iborra, Salvador
author
Sancho, David
funder
Unión Europea. Comisión Europea
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2017-12-01T07:37:26Z
2017-12-01T07:37:26Z
2015
Immunobiology. 2015; 220(2):175-84
10.1016/j.imbio.2014.09.013
0171-2985
Immunobiology
25269828
http://hdl.handle.net/20.500.12105/5520
Among myeloid immune receptors, C-type lectin receptors (CLRs) have a remarkable capacity to sense a variety of self and non-self ligands. The coupling of CLRs to different signal transduction modules is influenced not only by the receptor, but also by the nature, density and architecture of the ligand, which can affect the rate of receptor internalization and trafficking to diverse intracellular compartments. Understanding how the variety of self and non-self ligands triggers differential CLR signalling and function presents a fascinating biological challenge. Non-self ligands usually promote inflammation and immunity, whereas self ligands are frequently involved in communication and tolerance. But pathogens can mimic self-inhibitory signals to escape immune surveillance, and endogenous ligands can contribute to the sensing of pathogens through CLRs. In this review, we survey the complexity and flexibility in functional outcome found in the myeloid CLRs, which is not only based on their differing intracellular motifs, but is also conditioned by the physical nature, affinity and avidity of the ligand. (C) 2014 The Authors. Published by Elsevier GmbH.
eng
Innate immunity
C-type lectin receptors
Myeloid cells
PATTERN-RECOGNITION RECEPTOR
DENDRITIC CELL-RECEPTOR
INDUCED NEUTROPHIL ACTIVATION
SYK TYROSINE KINASE
DC-SIGN
FCR-GAMMA
INFLAMMATORY RESPONSES
CANDIDA-ALBICANS
IMMUNE-RESPONSES
DECTIN-2 RECOGNITION
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors
journal article
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SignallingVersatilityFollowingSelf_2015.pdf
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SignallingVersatilityFollowingSelf_2015.pdf.txt