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oai:repisalud.isciii.es:20.500.12105/55202024-09-27T08:03:18Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Iborra, Salvador author Sancho, David author 2015 Among myeloid immune receptors, C-type lectin receptors (CLRs) have a remarkable capacity to sense a variety of self and non-self ligands. The coupling of CLRs to different signal transduction modules is influenced not only by the receptor, but also by the nature, density and architecture of the ligand, which can affect the rate of receptor internalization and trafficking to diverse intracellular compartments. Understanding how the variety of self and non-self ligands triggers differential CLR signalling and function presents a fascinating biological challenge. Non-self ligands usually promote inflammation and immunity, whereas self ligands are frequently involved in communication and tolerance. But pathogens can mimic self-inhibitory signals to escape immune surveillance, and endogenous ligands can contribute to the sensing of pathogens through CLRs. In this review, we survey the complexity and flexibility in functional outcome found in the myeloid CLRs, which is not only based on their differing intracellular motifs, but is also conditioned by the physical nature, affinity and avidity of the ligand. (C) 2014 The Authors. Published by Elsevier GmbH. Immunobiology. 2015; 220(2):175-84 10.1016/j.imbio.2014.09.013 0171-2985 Immunobiology 25269828 http://hdl.handle.net/20.500.12105/5520 Innate immunity C-type lectin receptors Myeloid cells PATTERN-RECOGNITION RECEPTOR DENDRITIC CELL-RECEPTOR INDUCED NEUTROPHIL ACTIVATION SYK TYROSINE KINASE DC-SIGN FCR-GAMMA INFLAMMATORY RESPONSES CANDIDA-ALBICANS IMMUNE-RESPONSES DECTIN-2 RECOGNITION Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors