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oai:repisalud.isciii.es:20.500.12105/55172024-09-27T08:13:09Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud author Nagasawa, Satoi author Sedukhina, Anna S. author Nakagawa, Yuko author Maeda, Ichiro author Kubota, Manabu author Ohnuma, Shigeko author Tsugawa, Koichiro author Ohta, Tomohiko author Roche-Molina, Marta author Bernal, Juan Antonio author Narvaez, Ana J. author Jeyasekharan, Anand D. author Sato, Ko funder St. Marianna University (Japón) 2017-12-01T07:37:25Z 2017-12-01T07:37:25Z 2015 PLoS One. 2015 Feb 13;10(2):e0118002 10.1371/journal.pone.0118002 1932-6203 Plos One 25679396 http://hdl.handle.net/20.500.12105/5517 LSD1, a lysine-specific histone demethylase, is overexpressed in several types of cancers and linked to poor outcomes. In breast cancer, the significance of LSD1 overexpression is not clear. We have performed an in silico analysis to assess the relationship of LSD1 expression to clinical outcome. We demonstrate that LSD1 overexpression is a poor prognostic factor in breast cancer, especially in basal-like breast cancer, a subtype of breast cancer with aggressive clinical features. This link is also observed in samples of triple negative breast cancer. Interestingly, we note that overexpression of LSD1 correlates with down-regulation of BRCA1 in triple negative breast cancer. This phenomenon is also observed in in vitro models of basal-like breast cancer, and is associated with an increased sensitivity to PARP inhibitors. We propose therefore that high expression levels of the demethylase LSD1 is a potential prognostic factor of poor outcome in basal-like breast cancer, and that PARP inhibition may be a therapeutic strategy of interest in this poor prognostic subtype with overexpression of LSD1. eng GENE-EXPRESSION DATA MOLECULAR PORTRAITS DNA-REPAIR CARCINOMA ACTIVATION REPRESSION TUMORS LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition journal article URL https://repisalud.isciii.es/bitstreams/1e4682f7-89f6-4ecc-862e-750869e1f3f7/download File MD5 82eb478eb8e4c72baf1c99be9847ef7d 1710130 application/pdf OverexpressionIsAssociatedWithPoor_2015 URL https://repisalud.isciii.es/bitstreams/93c11cfe-172d-40d2-8994-57c048c397df/download File MD5 877284919b2ca719ee9085a2428edd24 32328 text/plain OverexpressionIsAssociatedWithPoor_2015.txt