2026-08-06T16:03:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/55152024-09-27T09:35:34Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sanchez-Gonzalez, Javier
author
Fernandez-Jimenez, Rodrigo
author
Nothnagel, Nils D.
author
Lopez-Martin, Gonzalo J.
author
Fuster, Valentin
author
Ibáñez, Borja
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Fundación Jesús Serra
funder
Fundación Interhospitalaria de Investigación Cardiovascular
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
2017-12-01T07:37:25Z
2017-12-01T07:37:25Z
2015
J Cardiovasc Magn Reson. 2015; 17(1):116
10.1186/s12968-015-0116-2
1532-429X
1097-6647
Journal of Cardiovascular Magnetic Resonance
25880970
http://hdl.handle.net/20.500.12105/5515
Background: In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered clinically. Dual-saturation acquisition also lacks a clinically-applicable procedure for optimizing parameter selection. Here we present a comprehensive validation study of dual-saturation strategy in vitro and in vivo. Methods: The impact of saturation time and profile ordering in acquisitions was systematically analyzed in a phantom consisting of 15 tubes containing different concentrations of contrast agent. In-vivo experiments in healthy pigs were conducted to evaluate the effect of R2{*} on the definition of the arterial input function (AIF) and to evaluate the relationship between R2{*} and R1 variations during first-pass of the contrast agent. Quantification by dual-saturation perfusion was compared with the reference-standard dual-bolus strategy in 11 pigs with different grades of myocardial perfusion. Results: Adequate flow estimation by the dual-saturation strategy is achieved with myocardial tissue saturation times around 100 ms (always < 30 ms of AIF), with the lowest echo time, and following a signal model for contrast conversion that takes into account the residual R2{*} effect and profile ordering. There was a good correlation and agreement between myocardial perfusion quantitation by dual-saturation and dual-bolus techniques (R-2 = 0.92, mean difference of 0.1 ml/min/g; myocardial perfusion ranges between 0.18 and 3.93 ml/min/g). Conclusions: The dual-saturation acquisition strategy produces accurate estimates of absolute myocardial perfusion in vivo. The procedure presented here can be applied with minimal interference in standard clinical procedures.
eng
Dual saturation acquisition strategy
Absolute quantitative cardiac perfusion
Cardiovascular magnetic resonance
CARDIOVASCULAR MAGNETIC-RESONANCE
CORONARY-ARTERY-DISEASE
NONINVASIVE DETECTION
T1 MEASUREMENTS
INPUT FUNCTION
DOGS
ISCHEMIA/REPERFUSION
ENHANCEMENT
T2-ASTERISK
RELAXATION
Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps
journal article
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Optimizationofdual-saturationsinglebolus_2015
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Optimizationofdual-saturationsinglebolus_2015.txt
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Optimizationofdual-saturationsinglebolus_2015.txt
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Optimizationofdual-saturationsinglebolus_2015.txt
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Optimizationofdual-saturationsinglebolus_2015.txt
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Optimizationofdual-saturationsinglebolus_2015.txt