2026-07-23T23:04:53Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/54112024-09-27T09:52:19Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Perez, Laura M.
author
Bernal, Aurora
author
de Lucas, Beatriz
author
San Martin, Nuria
author
Mastrangelo, Annalaura
author
Garcia, Antonia
author
Barbas, Coral
author
Galvez, Beatriz G.
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Ministerio de Economía y Competitividad (España)
2017-11-27T13:49:53Z
2017-11-27T13:49:53Z
2015
PLoS One. 2015; 10(4):e0123397
10.1371/journal.pone.0123397
1932-6203
PLoS ONE
25875023
http://hdl.handle.net/20.500.12105/5411
Adipose stem cells (ASCs) are an appealing source of cells for
therapeutic intervention; however, the environment from which ASCs are
isolated may impact their usefulness. Using a range of functional
assays, we have evaluated whether ASCs isolated from an obese
environment are comparable to cells from non-obese adipose tissue.
Results showed that ASCs isolated from obese tissue have a reduced
proliferative ability and a loss of viability together with changes in
telomerase activity and DNA telomere length, suggesting a decreased
self-renewal capacity. Metabolic analysis demonstrated that
mitochondrial content and function was impaired in obese-derived ASCs
resulting in changes in favored oxidative substrates. These findings
highlight the impact of obesity on adult stem properties. Hence, caution
should be exercised when considering the source of ASCs for cellular
therapies since their therapeutic potential may be impaired.
eng
MITOCHONDRIAL DYSFUNCTION
INSULIN-RESISTANCE
ENERGY-METABOLISM
PROGENITOR CELLS
SELF-RENEWAL
EXPRESSION
OCT4
RESPIRATION
ADIPOCYTES
GLYCOLYSIS
Altered Metabolic and Stemness Capacity of Adipose Tissue-Derived Stem
Cells from Obese Mouse and Human
journal article
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