2026-07-21T15:38:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/54042024-09-27T09:50:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Kosmalska, Anita Joanna
author
Casares, Laura
author
Elosegui-Artola, Alberto
author
Thottacherry, Joseph Jose
author
Moreno-Vicente, Roberto
author
Gonzalez-Tarrago, Victor
author
del Pozo, Miguel Angel
author
Mayor, Satyajit
author
Arroyo, Marino
author
Navajas, Daniel
author
Trepat, Xavier
author
Gauthier, Nils C.
author
Roca-Cusachs, Pere
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Government of Catalonia (España)
funder
Fundación La Caixa
funder
Fundación La Marató TV3
funder
Institució Catalana de Recerca i Estudis Avançats
funder
National Research Foundation (Singapur)
2017-11-27T13:49:52Z
2017-11-27T13:49:52Z
2015
Nat Commun. 2015; 6:7292
10.1038/ncomms8292
2041-1723
Nature Communications
26073653
http://hdl.handle.net/20.500.12105/5404
Biological processes in any physiological environment involve changes in
cell shape, which must be accommodated by their physical envelope-the
bilayer membrane. However, the fundamental biophysical principles by
which the cell membrane allows for and responds to shape changes remain
unclear. Here we show that the 3D remodelling of the membrane in
response to a broad diversity of physiological perturbations can be
explained by a purely mechanical process. This process is passive,
local, almost instantaneous, before any active remodelling and generates
different types of membrane invaginations that can repeatedly store and
release large fractions of the cell membrane. We further demonstrate
that the shape of those invaginations is determined by the minimum
elastic and adhesive energy required to store both membrane area and
liquid volume at the cell-substrate interface. Once formed, cells
reabsorb the invaginations through an active process with duration of
the order of minutes.
eng
ALVEOLAR EPITHELIAL-CELLS
SURFACE-AREA REGULATION
LIVING CELLS
TENSION
DYNAMICS
SHAPE
EXOCYTOSIS
MIGRATION
NEURONS
STRESS
Physical principles of membrane remodelling during cell
mechanoadaptation
journal article
URL
https://repisalud.isciii.es/bitstreams/a20b7b7d-a8ea-4b63-aba1-3f3c3ec06e22/download
File
MD5
50680f9e85f7f70de670db6a28ed4cfc
7350489
application/pdf
PhysicalPrinciplesOfMembraneRemodelling_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/4cdeca40-f7e7-44aa-8a67-dd9ac9e05ab1/download
File
MD5
bcd7fcd3e223db761a9730f04a21b7fc
2047068
application/pdf
PhysicalPrinciplesOfMembraneRemodelling_2015_Suppl1.pdf
URL
https://repisalud.isciii.es/bitstreams/3f32d4c6-f30e-49bc-b03f-a83276868930/download
File
MD5
e2c6bcbda3a4b19805363cd4d94d74a0
319342
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s2.avi
URL
https://repisalud.isciii.es/bitstreams/b7b482cd-e743-438b-81ad-547a946dc4b8/download
File
MD5
bc1621736603aa2c61af8713e1cfc3e1
809556
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s3.avi
URL
https://repisalud.isciii.es/bitstreams/3ad6d4ac-2051-4708-82f7-d3ae1d3517ff/download
File
MD5
bda02327e6a5269aa9d03bb11948a6de
1006672
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s4.avi
URL
https://repisalud.isciii.es/bitstreams/70a8cdb9-ab76-4fd2-8376-baa2b036098b/download
File
MD5
372d8a7122a0a9caf6479d5265c300aa
899888
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s5.avi
URL
https://repisalud.isciii.es/bitstreams/f3ed58cd-d76c-492b-ac6c-382d08ee1ebd/download
File
MD5
3f62778f5b80de47026d8698e36b31e7
1441856
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s6.avi
URL
https://repisalud.isciii.es/bitstreams/6a957ae0-6203-4f55-9ae7-4f4c521e8520/download
File
MD5
05ec7e0901e94287231d7ed5c83c13a9
1534182
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s7.avi
URL
https://repisalud.isciii.es/bitstreams/7e38edd7-de41-424a-bb2e-62b260a62b42/download
File
MD5
eed3c9a3427588a7f46cc4b86e42f575
1553102
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s8.avi
URL
https://repisalud.isciii.es/bitstreams/a3372820-efba-40ff-99d3-c0380b45972e/download
File
MD5
dd90f005f9f3f5a9633054cd6055e037
2587760
application/octet-stream
PhysicalPrinciplesOfMembraneRemodelling_2015-s9.avi
URL
https://repisalud.isciii.es/bitstreams/d314575e-0adb-4489-923e-90b6154b9f47/download
File
MD5
43759a7b7883b48a1cd4aba09ef778b6
56162
text/plain
PhysicalPrinciplesOfMembraneRemodelling_2015.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/8e4138ea-ec54-4ef4-8328-9a97b6936d4d/download
File
MD5
fd49fec4cb1c776150708dbaaf7f2dba
21545
text/plain
PhysicalPrinciplesOfMembraneRemodelling_2015_Suppl1.pdf.txt