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oai:repisalud.isciii.es:20.500.12105/53972024-10-31T11:40:09Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud author Saravia, Gabriela author Civeira, Fernando author Hurtado-Roca, Yamilee author Andrés, Eva author Leon, Montserrat author Pocovi, Miguel author Ordovas, Jose M author Guallar, Eliseo author Fernandez-Ortiz, Antonio author Casasnovas, Jose Antonio author Laclaustra, Martin funder Instituto de Salud Carlos III funder Gobierno de Perú funder Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 2017-11-27T13:49:51Z 2017-11-27T13:49:51Z 2015 PLoS One. 2015; 10(8):e0132244 1932-6203 http://hdl.handle.net/20.500.12105/5397 26241903 10.1371/journal.pone.0132244 PLoS One Background and Aims Glycated hemoglobin (HbA1c) is currently used to diagnose diabetes mellitus, while insulin has been relegated to research. Both, however, may help understanding the metabolic syndrome and profiling patients. We examined the association of HbA1c and fasting insulin with clustering of metabolic syndrome criteria and insulin resistance as two essential characteristics of the metabolic syndrome. Methods We used baseline data from 3200 non-diabetic male participants in the Aragon Workers' Health Study. We conducted analysis to estimate age-adjusted odds ratios (ORs) across tertiles of HbA1c and insulin. Fasting glucose and Homeostatic model assessment - Insulin Resistance were used as reference. Here we report the uppermost-to-lowest tertile ORs (95\% CI). Results Mean age (SD) was 48.5 (8.8) years and 23\% of participants had metabolic syndrome. The ORs for metabolic syndrome criteria tended to be higher across HbA1c than across glucose, except for high blood pressure. Insulin was associated with the criteria more strongly than HbA1c and similarly to Homeostatic model assessment - Insulin Resistance (HOMA-IR). For metabolic syndrome, the OR of HbA1c was 2.68, of insulin, 11.36, of glucose, 7.03, and of HOMA-IR, 14.40. For the clustering of 2 or more non-glycemic criteria, the OR of HbA1c was 2.10, of insulin, 8.94, of glucose, 1.73, and of HOMA-IR, 7.83. All ORs were statistically significant. The areas under the receiver operating characteristics curves for metabolic syndrome were 0.670 (across HbA1c values) and 0.770 (across insulin values), and, for insulin resistance, 0.647 (HbA1c) and 0.995 (insulin). Among non-metabolic syndrome patients, a small insulin elevation identified risk factor clustering. Conclusions HbA1c and specially insulin levels were associated with metabolic syndrome criteria, their clustering, and insulin resistance. Insulin could provide early information in subjects prone to develop metabolic syndrome. eng CARDIOVASCULAR RISK DIABETES-MELLITUS RESISTANCE ADULTS HYPERINSULINEMIA ASSOCIATION DISEASE GLUCOSE A1C SENSITIVITY Glycated Hemoglobin, Fasting Insulin and the Metabolic Syndrome in Males. Cross-Sectional Analyses of the Aragon Workers' Health Study Baseline journal article URL https://repisalud.isciii.es/bitstreams/46588c74-3484-4658-b440-e29d9cb82753/download File MD5 fd036cd1ec16edcadddf2fb1701b38fb 1020904 application/pdf GlycatedHemoglobinFastingInsulin_2015.pdf URL https://repisalud.isciii.es/bitstreams/baec2d87-35d9-4844-b279-f2adc7f4ecbb/download File MD5 ea6dc4cdb94c05c0e8179b461d1f8fb5 23340 application/vnd.openxmlformats-officedocument.wordprocessingml.document GlycatedHemoglobinFastingInsulin_2015_suppl.docx URL https://repisalud.isciii.es/bitstreams/1be75695-7707-4a46-a8f8-25b85610b29c/download File MD5 0737039c445312bd5d910d62a73522c4 47139 text/plain GlycatedHemoglobinFastingInsulin_2015.pdf.txt URL https://repisalud.isciii.es/bitstreams/16f03002-3277-4dc6-be64-7154fd27a954/download File MD5 04f4af946a64211a3059ae8662cc97b0 7914 text/plain GlycatedHemoglobinFastingInsulin_2015_suppl.docx.txt