2026-07-01T11:24:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/53912024-09-27T09:07:41Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Bednarek, Dorota
author
Gonzalez-Rosa, Juan Manuel
author
Guzman-Martinez, Gabriela
author
Gutierrez-Gutierrez, Oscar
author
Aguado, Tania
author
Sanchez-Ferrer, Carlota
author
Marques, Ines Joao
author
Galardi-Castilla, Maria
author
de Diego, Irene
author
Gomez, Manuel J
author
Cortes, Alfonso
author
Zapata, Agustin
author
Jimenez-Borreguero, Luis J.
author
Mercader, Nadia
author
Flores, Ignacio
funder
Ministerio de Economía, Innovación y Competitividad (España)
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea
2017-11-27T13:49:50Z
2017-11-27T13:49:50Z
2015
Cell Rep. 2015; 12(10):1691-703
10.1016/j.celrep.2015.07.064
2211-1247
Cell Reports
26321646
http://hdl.handle.net/20.500.12105/5391
After myocardial infarction in humans, lost cardiomyocytes are replaced
by an irreversible fibrotic scar. In contrast, zebrafish hearts
efficiently regenerate after injury. Complete regeneration of the
zebrafish heart is driven by the strong proliferation response of its
cardiomyocytes to injury. Here we show that, after cardiac injury in
zebrafish, telomerase becomes hyperactivated, and telomeres elongate
transiently, preceding a peak of cardiomyocyte proliferation and full
organ recovery. Using a telomerase-mutant zebrafish model, we found that
telomerase loss drastically decreases cardiomyocyte proliferation and
fibrotic tissue regression after cryoinjury and that cardiac function
does not recover. The impaired cardiomyocyte proliferation response is
accompanied by the absence of cardiomyocytes with long telomeres and an
increased proportion of cardiomyocytes showing DNA damage and senescence
characteristics. These findings demonstrate the importance of telomerase
function in heart regeneration and highlight the potential of telomerase
therapy as a means of stimulating cell proliferation upon myocardial
infarction.
eng
CARDIOMYOCYTE PROLIFERATION
MYOCARDIAL-INFARCTION
INJURY
CRYOINJURY
CAPACITY
MODEL
HEMATOPOIESIS
ACTIVATION
EXPRESSION
FAILURE
Telomerase Is Essential for Zebrafish Heart Regeneration
journal article
URL
https://repisalud.isciii.es/bitstreams/67e51b5d-7673-48a5-8a0f-a1bb7eadc8e6/download
File
MD5
d2ebc058e6b2623aa29a63de10d0722f
6563236
application/pdf
TelomeraseIsEssentialforZebrafish_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/d74f9eaf-bf6b-4d61-957a-698304f38eb6/download
File
MD5
b64b612ad1b1e308b98cfbc0f367b410
18867605
application/pdf
TelomeraseIsEssentialforZebrafish_2015_suppl1.pdf
URL
https://repisalud.isciii.es/bitstreams/d8790ec3-fdcb-4091-8df3-f044396cf799/download
File
MD5
1f512110bb6b9a3cb9113b7bf678b194
3594835
application/octet-stream
TelomeraseIsEssentialforZebrafish_2015_suppl2.mp4
URL
https://repisalud.isciii.es/bitstreams/857ff9bc-07c2-4ec3-8e96-c2d488144488/download
File
MD5
40e6095f2be7f0ac1841cb48be8d5029
13775246
application/octet-stream
TelomeraseIsEssentialforZebrafish_2015_suppl3.mp4
URL
https://repisalud.isciii.es/bitstreams/f4bc9e5f-573d-477c-a1ef-ce746082b391/download
File
MD5
458f182bfe16ddb76c8ee4d9f6ded038
3638494
application/octet-stream
TelomeraseIsEssentialforZebrafish_2015_suppl4.mp4
URL
https://repisalud.isciii.es/bitstreams/3498471c-c588-4795-83a7-7f5de47ddf03/download
File
MD5
d3962e944d9808e8a98a97cbef630f9a
5777275
application/octet-stream
TelomeraseIsEssentialforZebrafish_2015_suppl5.mp4
URL
https://repisalud.isciii.es/bitstreams/f4eb3fac-d112-4c34-aeed-9d0da9688a69/download
File
MD5
036e4d6132e2f8958241d7d709cc1433
2071854
application/octet-stream
TelomeraseIsEssentialforZebrafish_2015_suppl6.mp4
URL
https://repisalud.isciii.es/bitstreams/3a9dd07d-0b54-43b1-a5c5-247f4f3190db/download
File
MD5
4c6610a086d8bdc827e13cf1496f3b11
2049115
application/octet-stream
TelomeraseIsEssentialforZebrafish_2015_suppl7.mp4
URL
https://repisalud.isciii.es/bitstreams/433d0b05-db60-4ad1-9153-3ff6a97c0d3e/download
File
MD5
6487193cbbff83815235367e93d9fb07
60166
text/plain
TelomeraseIsEssentialforZebrafish_2015.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/c0b4e669-e0c7-45af-977b-cb66b983c966/download
File
MD5
45ac840cf29069505d8aa9ab8d827367
14526
text/plain
TelomeraseIsEssentialforZebrafish_2015_suppl1.pdf.txt