2026-07-22T01:50:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/53902024-09-27T08:11:40Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cioffi, Michele
author
Vallespinos-Serrano, Mireia
author
Trabulo, Sara M.
author
Jose Fernandez-Marcos, Pablo
author
Firment, Ashley N.
author
Vazquez, Berta N.
author
Vieira, Catarina R.
author
Mulero, Francisca
author
Camara, Juan A.
author
Cronin, Ultan P.
author
Perez, Manuel
author
Soriano, Joaquim
author
Galvez, Beatriz G.
author
Castells-Garcia, Alvaro
author
Haage, Verena
author
Raj, Deepak
author
Megias Vazquez, Diego
author
Hahn, Stephan
author
Serrano, Lourdes
author
Moon, Anne
author
Aicher, Alexandra
author
Heeschen, Christopher
funder
European Commission
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Fundación La Caixa
2017-11-27T13:49:49Z
2017-11-27T13:49:49Z
2015
Cell Rep. 2015; 12(10):1594-605
10.1016/j.celrep.2015.08.006
2211-1247
Cell Reports
26321631
http://hdl.handle.net/20.500.12105/5390
Conquering obesity has become a major socioeconomic challenge. Here, we
show that reduced expression of the miR-25-93-106b cluster, or miR-93
alone, increases fat mass and, subsequently, insulin resistance.
Mechanistically, we discovered an intricate interplay between enhanced
adipocyte precursor turnover and increased adipogenesis. First, miR-93
controls Tbx3, thereby limiting self-renewal in early adipocyte
precursors. Second, miR-93 inhibits the metabolic target Sirt7, which we
identified as a major driver of in vivo adipogenesis via induction of
differentiation and maturation of early adipocyte precursors. Using
mouse parabiosis, obesity in mir-25-93-106b(-/-) mice could be rescued
by restoring levels of circulating miRNA and subsequent inhibition of
Tbx3 and Sirt7. Downregulation of miR-93 also occurred in obese ob/ob
mice, and this phenocopy of mir-25-93-106b(-/-) was partially reversible
with injection of miR-93 mimics. Our data establish miR-93 as a negative
regulator of adipogenesis and a potential therapeutic option for obesity
and the metabolic syndrome.
eng
ADIPOCYTE DIFFERENTIATION
STEM-CELLS
INSULIN-RESISTANCE
IN-VIVO
TISSUE
IDENTIFICATION
REGULATOR
OBESITY
GROWTH
RISK
MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3
journal article
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MiR-93ControlsAdiposity_2015.pdf
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MiR-93ControlsAdiposity_2015_suppl1.pdf
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MiR-93ControlsAdiposity_2015.pdf.txt
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MiR-93ControlsAdiposity_2015_suppl1.pdf.txt