2026-06-14T03:33:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/52612024-09-27T10:01:46Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Santos, Arnoldo author Fernandez-Friera, Leticia author Villalba-Orero, Maria author Lopez-Melgar, Beatriz author Espana, Samuel author Mateo, Jesus author Mota, Ruben A. author Jimenez-Borreguero, Luis J. author Ruiz-Cabello, Jesus author 2015 Cardiovascular imaging has become an indispensable tool for patient diagnosis and follow up. Probably the wide clinical applications of imaging are due to the possibility of a detailed and high quality description and quantification of cardiovascular system structure and function. Also phenomena that involve complex physiological mechanisms and biochemical pathways, such as inflammation and ischemia, can be visualized in a non-destructive way. The widespread use and evolution of imaging would not have been possible without animal studies. Animal models have allowed for instance, (i) the technical development of different imaging tools, (ii) to test hypothesis generated from human studies and finally, (vi) to evaluate the translational relevance assessment of in vitro and ex-vivo results. In this review, we will critically describe the contribution of animal models to the use of biomedical imaging in cardiovascular medicine. We will discuss the characteristics of the most frequent models used in/for imaging studies. We will cover the major findings of animal studies focused in the cardiovascular use of the repeatedly used imaging techniques in clinical practice and experimental studies. We will also describe the physiological findings and/or learning processes for imaging applications coming from models of the most common cardiovascular diseases. In these diseases, imaging research using animals has allowed the study of aspects such as: ventricular size, shape, global function, and wall thickening, local myocardial function, myocardial perfusion, metabolism and energetic assessment, infarct quantification, vascular lesion characterization, myocardial fiber structure, and myocardial calcium uptake. Finally we will discuss the limitations and future of imaging research with animal models. Front Pharmacol. 2015; 6:227 10.3389/fphar.2015.00227 1663-9812 Frontiers in Pharmacology 26539113 http://hdl.handle.net/20.500.12105/5261 Animal models Biomedical imaging Heart failure Myocardial infarction Pulmonary hypertension Atherosclerosis CARDIAC MAGNETIC-RESONANCE ACUTE MYOCARDIAL-INFARCTION PULMONARY ARTERIAL-HYPERTENSION VENTRICULAR DIASTOLIC FUNCTION POSITRON-EMISSION-TOMOGRAPHY ISCHEMIA-REPERFUSION INJURY IN-VIVO ASSESSMENT HIGH-RESOLUTION ECHOCARDIOGRAPHY AMERICAN-HEART-ASSOCIATION ROW COMPUTED-TOMOGRAPHY Cardiovascular imaging: what have we learned from animal models?