2026-08-12T20:37:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52582024-09-27T09:26:14Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fernandez-Jimenez, Rodrigo
author
Sanchez-Gonzalez, Javier
author
Aguero, Jaume
author
del Trigo, Maria
author
Galan-Arriola, Carlos
author
Fuster, Valentin
author
Ibáñez, Borja
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación Jesús Serra
funder
Fundación Interhospitalaria de Investigación Cardiovascular
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Fundación ProCNIC
2017-10-30T13:32:28Z
2017-10-30T13:32:28Z
2015
J Cardiovasc Magn Reson. 2015; 17(1):92
10.1186/s12968-015-0199-9
1532-429X
1097-6647
Journal of Cardiovascular Magnetic Resonance
26538198
http://hdl.handle.net/20.500.12105/5258
Background: Several T2-mapping sequences have been recently proposed to quantify myocardial edema by providing T2 relaxation time values. However, no T2-mapping sequence has ever been validated against actual myocardial water content for edema detection. In addition, these T2-mapping sequences are either time-consuming or require specialized software for data acquisition and/or post-processing, factors impeding their routine clinical use. Our objective was to obtain in vivo validation of a sequence for fast and accurate myocardial T2-mapping (T2 gradient-spin-echo [GraSE]) that can be easily integrated in routine protocols. Methods: The study population comprised 25 pigs. Closed-chest 40 min ischemia/reperfusion was performed in 20 pigs. Pigs were sacrificed at 120 min (n = 5), 24 h (n = 5), 4 days (n = 5) and 7 days (n = 5) after reperfusion, and heart tissue extracted for quantification of myocardial water content. For the evaluation of T2 relaxation time, cardiovascular magnetic resonance (CMR) scans, including T2 turbo-spin-echo (T2-TSE, reference standard) mapping and T2-GraSE mapping, were performed at baseline and at every follow-up until sacrifice. Five additional pigs were sacrificed after baseline CMR study and served as controls. Results: Acquisition of T2-GraSE mapping was significantly (3-fold) faster than conventional T2-TSE mapping. Myocardial T2 relaxation measurements performed by T2-TSE and T2-GraSE mapping demonstrated an almost perfect correlation (R-2 = 0.99) and agreement with no systematic error between techniques. The two T2-mapping sequences showed similarly good correlations with myocardial water content: R-2 = 0.75 and R-2 = 0.73 for T2-TSE and T2-GraSE mapping, respectively. Conclusions: We present the first in vivo validation of T2-mapping to assess myocardial edema. Given its shorter acquisition time and no requirement for specific software for data acquisition or post-processing, fast T2-GraSE mapping of the myocardium offers an attractive alternative to current CMR sequences for T2 quantification.
eng
Cardiovascular magnetic resonance
T2-mapping
Imaging
Myocardial infarction
Edema
Water content
CARDIAC MAGNETIC-RESONANCE
TISSUE CHARACTERIZATION
RELAXATION-TIMES
INFARCTION
RISK
INJURY
AREA
CMR
CONTROVERSIES
REPERFUSION
Fast T2 gradient-spin-echo (T2-GraSE) mapping for myocardial edema quantification: first in vivo validation in a porcine model of ischemia/reperfusion
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