2026-08-29T15:33:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52552024-09-27T10:07:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Bhavesh, Riju
author
Lechuga-Vieco, Ana V.
author
Ruiz-Cabello, Jesus
author
Herranz, Fernando
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea
2017-10-30T13:32:28Z
2017-10-30T13:32:28Z
2015
Nanomaterials. 2015; 5(4):1880-90
10.3390/nano5041880
2079-4991
Nanomaterials
28347101
http://hdl.handle.net/20.500.12105/5255
Iron oxide nanoparticles have long been studied as a T-2 contrast agent in MRI due to their superparamagnetic behavior. T-1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T-1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.
eng
iron oxide nanoparticles
MRI
T-1 contrast
Microwave
MRI CONTRAST AGENTS
MAGNETIC NANOPARTICLES
T-1
T-1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis
journal article
URL
https://repisalud.isciii.es/bitstreams/7de7e9b1-82fd-486f-983b-b1a305146046/download
File
MD5
160c02cb1be485415bd21068eceae506
666082
application/pdf
T1-MRIFluorescentIronOxide_2015
URL
https://repisalud.isciii.es/bitstreams/e14accd1-1ce8-4134-bb87-6a98b7971822/download
File
MD5
df9607aac199ec5b750a8b25b11b325c
29682
text/plain
T1-MRIFluorescentIronOxide_2015.txt