2026-07-23T17:12:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52452024-09-27T09:28:59Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rocha-Perugini, Vera
author
Sanchez-Madrid, Francisco
author
Martinez del Hoyo, Gloria
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2017-10-30T13:32:26Z
2017-10-30T13:32:26Z
2016
Front Immunol. 2016; 6:653
10.3389/fimmu.2015.00653
1664-3224
Frontiers in Immunology
26793193
http://hdl.handle.net/20.500.12105/5245
Tetraspanin-enriched microdomains (TEMs) are specialized membrane platforms driven by protein protein interactions that integrate membrane receptors and adhesion molecules. Tetraspanins participate in antigen recognition and presentation by antigen-presenting cells (APCs) through the organization of pattern-recognition receptors (PRRs) and their downstream induced signaling, as well as the regulation of MHC-II-peptide trafficking. T lymphocyte activation is triggered upon specific recognition of antigens present on the APC surface during immunological synapse (IS) formation. This dynamic process is characterized by a defined spatial organization involving the compartmentalization of receptors and adhesion molecules in specialized membrane domains that are connected to the underlying cytoskeleton and signaling molecules. Tetraspanins contribute to the spatial organization and maturation of the IS by controlling receptor clustering and local accumulation of adhesion receptors and integrins, their downstream signaling, and linkage to the actin cytoskeleton. This review offers a perspective on the important role of TEMs in the regulation of antigen recognition and presentation and in the dynamics of IS architectural organization.
eng
Tetraspanins
Tetraspanin-enriched microdomains
Adhesion receptors
Immunological synapse
T-cell activation
T-CELL-ACTIVATION
MHC CLASS-II
HEPATITIS-C VIRUS
ADHESION-DEPENDENT ACTIVATION
IMMATURE DENDRITIC CELLS
TRANSMEMBRANE-4 SUPERFAMILY
ENRICHED MICRODOMAINS
INTEGRIN ACTIVATION
IMMUNE SYNAPSE
LIPID RAFTS
Function and Dynamics of Tetraspanins during Antigen Recognition and Immunological Synapse Formation
journal article
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FunctionAndDynamicsOf_2016.txt