2026-06-14T03:37:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52442024-09-27T08:15:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Gulia-Nuss, Monika
author
Nuss, Andrew B.
author
Meyer, Jason M.
author
Sonenshine, Daniel E.
author
Roe, R. Michael
author
Waterhouse, Robert M.
author
Sattelle, David B.
author
de la Fuente, Jose
author
Ribeiro, Jose M.
author
Megy, Karine
author
Thimmapuram, Jyothi
author
Miller, Jason R.
author
Walenz, Brian P.
author
Koren, Sergey
author
Hostetler, Jessica B.
author
Thiagarajan, Mathangi
author
Joardar, Vinita S.
author
Hannick, Linda I.
author
Bidwell, Shelby
author
Hammond, Martin P.
author
Young, Sarah
author
Zeng, Qiandong
author
Abrudan, Jenica L.
author
Almeida, Francisca C.
author
Ayllon, Nieves
author
Bhide, Ketaki
author
Bissinger, Brooke W.
author
Bonzon-Kulichenko, Elena
author
Buckingham, Steven D.
author
Caffrey, Daniel R.
author
Caimano, Melissa J.
author
Croset, Vincent
author
Driscoll, Timothy
author
Gilbert, Don
author
Gillespie, Joseph J.
author
Giraldo-Calderon, Gloria I.
author
Grabowski, Jeffrey M.
author
Jiang, David
author
Khalil, Sayed M. S.
author
Kim, Donghun
author
Kocan, Katherine M.
author
Koci, Juraj
author
Kuhn, Richard J.
author
Kurtti, Timothy J.
author
Lees, Kristin
author
Lang, Emma G.
author
Kennedy, Ryan C.
author
Kwon, Hyeogsun
author
Perera, Rushika
author
Qi, Yumin
author
Radolf, Justin D.
author
Sakamoto, Joyce M.
author
Sanchez-Gracia, Alejandro
author
Severo, Maiara S.
author
Silverman, Neal
author
Simo, Ladislav
author
Tojo, Marta
author
Tornador, Cristian
author
Van Zee, Janice P.
author
Vazquez, Jesus
author
Vieira, Filipe G.
author
Villar, Margarita
author
Wespiser, Adam R.
author
Yang, Yunlong
author
Zhu, Jiwei
author
Arensburger, Peter
author
Pietrantonio, Patricia V.
author
Barker, Stephen C.
author
Shao, Renfu
author
Zdobnov, Evgeny M.
author
Hauser, Frank
author
Grimmelikhuijzen, Cornelis J. P.
author
Park, Yoonseong
author
Rozas, Julio
author
Benton, Richard
author
Pedra, Joao H. F.
author
Nelson, David R.
author
Unger, Maria F.
author
Tubio, Jose M. C.
author
Tu, Zhijian
author
Robertson, Hugh M.
author
Shumway, Martin
author
Sutton, Granger
author
Wortman, Jennifer R.
author
Lawson, Daniel
author
Wikel, Stephen K.
author
Nene, Vishvanath M.
author
Fraser, Claire M.
author
Collins, Frank H.
author
Birren, Bruce
author
Nelson, Karen E.
author
Caler, Elisabet
author
Hill, Catherine A.
funder
NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)
funder
National Institutes of Health (Estados Unidos)
funder
Australian Research Council
funder
Ministerio de Ciencia e Innovación (España)
funder
United States Department of Health and Human Services
funder
National Science Foundation (Estados Unidos)
funder
Xunta de Galicia (España)
funder
Unión Europea. Comisión Europea
funder
United States Department of Agriculture. National Institute of Food and Agriculture
funder
Texas AgriLife Research
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Swiss National Science Foundation
funder
Fundação para a Ciência e Tecnologia (Portugal)
funder
Lundbeck Foundation
funder
Broad Genomics Platform
2017-10-30T13:32:26Z
2017-10-30T13:32:26Z
2016
10.1038/ncomms10507
2041-1723
Nature Communications
26856261
http://hdl.handle.net/20.500.12105/5244
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing similar to 57\% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host `questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
eng
ANAPLASMA-PHAGOCYTOPHILUM INFECTION
BEETLE TRIBOLIUM-CASTANEUM
BOOPHILUS-MICROPLUS
CATTLE TICK
CHEMOSENSORY RECEPTORS
EVOLUTIONARY ANALYSES
UNITED-STATES
LIFE-STYLE
DROSOPHILA
PROTEIN
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
journal article
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GenomicInsightsIntoThe_2016
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GenomicInsightsIntoThe_2016_suppl
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https://repisalud.isciii.es/bitstreams/a1d5b709-a104-46e0-b570-928f5397d126/download
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GenomicInsightsIntoThe_2016.txt
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GenomicInsightsIntoThe_2016_suppl.txt