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oai:repisalud.isciii.es:20.500.12105/52442024-09-27T08:15:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Gulia-Nuss, Monika author Nuss, Andrew B. author Meyer, Jason M. author Sonenshine, Daniel E. author Roe, R. Michael author Waterhouse, Robert M. author Sattelle, David B. author de la Fuente, Jose author Ribeiro, Jose M. author Megy, Karine author Thimmapuram, Jyothi author Miller, Jason R. author Walenz, Brian P. author Koren, Sergey author Hostetler, Jessica B. author Thiagarajan, Mathangi author Joardar, Vinita S. author Hannick, Linda I. author Bidwell, Shelby author Hammond, Martin P. author Young, Sarah author Zeng, Qiandong author Abrudan, Jenica L. author Almeida, Francisca C. author Ayllon, Nieves author Bhide, Ketaki author Bissinger, Brooke W. author Bonzon-Kulichenko, Elena author Buckingham, Steven D. author Caffrey, Daniel R. author Caimano, Melissa J. author Croset, Vincent author Driscoll, Timothy author Gilbert, Don author Gillespie, Joseph J. author Giraldo-Calderon, Gloria I. author Grabowski, Jeffrey M. author Jiang, David author Khalil, Sayed M. S. author Kim, Donghun author Kocan, Katherine M. author Koci, Juraj author Kuhn, Richard J. author Kurtti, Timothy J. author Lees, Kristin author Lang, Emma G. author Kennedy, Ryan C. author Kwon, Hyeogsun author Perera, Rushika author Qi, Yumin author Radolf, Justin D. author Sakamoto, Joyce M. author Sanchez-Gracia, Alejandro author Severo, Maiara S. author Silverman, Neal author Simo, Ladislav author Tojo, Marta author Tornador, Cristian author Van Zee, Janice P. author Vazquez, Jesus author Vieira, Filipe G. author Villar, Margarita author Wespiser, Adam R. author Yang, Yunlong author Zhu, Jiwei author Arensburger, Peter author Pietrantonio, Patricia V. author Barker, Stephen C. author Shao, Renfu author Zdobnov, Evgeny M. author Hauser, Frank author Grimmelikhuijzen, Cornelis J. P. author Park, Yoonseong author Rozas, Julio author Benton, Richard author Pedra, Joao H. F. author Nelson, David R. author Unger, Maria F. author Tubio, Jose M. C. author Tu, Zhijian author Robertson, Hugh M. author Shumway, Martin author Sutton, Granger author Wortman, Jennifer R. author Lawson, Daniel author Wikel, Stephen K. author Nene, Vishvanath M. author Fraser, Claire M. author Collins, Frank H. author Birren, Bruce author Nelson, Karen E. author Caler, Elisabet author Hill, Catherine A. author 2016 Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing similar to 57\% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host `questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent. 10.1038/ncomms10507 2041-1723 Nature Communications 26856261 http://hdl.handle.net/20.500.12105/5244 ANAPLASMA-PHAGOCYTOPHILUM INFECTION BEETLE TRIBOLIUM-CASTANEUM BOOPHILUS-MICROPLUS CATTLE TICK CHEMOSENSORY RECEPTORS EVOLUTIONARY ANALYSES UNITED-STATES LIFE-STYLE DROSOPHILA PROTEIN Genomic insights into the Ixodes scapularis tick vector of Lyme disease