2026-05-21T23:03:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52392024-09-27T08:18:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Giudice, Girolamo
author
Sanchez-Cabo, Fatima
author
Torroja, Carlos
author
Lara-Pezzi, Enrique
funder
European Commission
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
2017-10-30T13:32:25Z
2017-10-30T13:32:25Z
2016
Database (Oxford). 2016; 2016:baw035
10.1093/database/baw035
1758-0463
Database-The Journal of Biological Database and Curation
27055826
http://hdl.handle.net/20.500.12105/5239
RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA transport, splicing, polyadenylation and stability. Understanding the interaction between RBPs and RNA is key to improve our knowledge of RNA processing, localization and regulation in a global manner. Despite advances in recent years, a unified non-redundant resource that includes information on experimentally validated motifs, RBPs and integrated tools to exploit this information is lacking. Here, we developed a database named ATtRACT (available at http://attract.cnic.es) that compiles information on 370 RBPs and 1583 RBP consensus binding motifs, 192 of which are not present in any other database. To populate ATtRACT we (i) extracted and hand-curated experimentally validated data from CISBP-RNA, SpliceAid-F, RBPDB databases, (ii) integrated and updated the unavailable ASD database and (iii) extracted information from Protein-RNA complexes present in Protein Data Bank database through computational analyses. ATtRACT provides also efficient algorithms to search a specific motif and scan one or more RNA sequences at a time. It also allows discovering de novo motifs enriched in a set of related sequences and compare them with the motifs included in the database.
eng
GENE-REGULATION
NUCLEIC-ACID
WEB SERVER
DISCOVERY
SEQUENCES
PROGRAM
ATtRACT-a database of RNA-binding proteins and associated motifs
journal article
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ATtRACTDatabaseOfRNA-Binding_2016
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ATtRACTDatabaseOfRNA-Binding_2016.txt