2026-08-10T01:24:43Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/52392024-09-27T08:18:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Giudice, Girolamo author Sanchez-Cabo, Fatima author Torroja, Carlos author Lara-Pezzi, Enrique author 2016 RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA transport, splicing, polyadenylation and stability. Understanding the interaction between RBPs and RNA is key to improve our knowledge of RNA processing, localization and regulation in a global manner. Despite advances in recent years, a unified non-redundant resource that includes information on experimentally validated motifs, RBPs and integrated tools to exploit this information is lacking. Here, we developed a database named ATtRACT (available at http://attract.cnic.es) that compiles information on 370 RBPs and 1583 RBP consensus binding motifs, 192 of which are not present in any other database. To populate ATtRACT we (i) extracted and hand-curated experimentally validated data from CISBP-RNA, SpliceAid-F, RBPDB databases, (ii) integrated and updated the unavailable ASD database and (iii) extracted information from Protein-RNA complexes present in Protein Data Bank database through computational analyses. ATtRACT provides also efficient algorithms to search a specific motif and scan one or more RNA sequences at a time. It also allows discovering de novo motifs enriched in a set of related sequences and compare them with the motifs included in the database. Database (Oxford). 2016; 2016:baw035 10.1093/database/baw035 1758-0463 Database-The Journal of Biological Database and Curation 27055826 http://hdl.handle.net/20.500.12105/5239 GENE-REGULATION NUCLEIC-ACID WEB SERVER DISCOVERY SEQUENCES PROGRAM ATtRACT-a database of RNA-binding proteins and associated motifs