2026-07-22T05:25:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52382024-09-27T08:29:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Talavera-Garcia, Eva
author
Delgado-Lista, Javier
author
García-Ríos, Antonio
author
Delgado-Casado, Nieves
author
Gomez-Luna, Purificacion
author
Gomez-Garduno, Angela
author
Gomez-Delgado, Francisco
author
Alcala-Diaz, Juan Francisco
author
Yubero-Serrano, Elena
author
Marin, Carmen
author
Perez-Caballero, Ana I.
author
Fuentes-Jimenez, Francisco J.
author
Camargo, Antonio
author
Rodriguez-Cantalejo, Fernando
author
Tinahones, Francisco J.
author
Ordovas, Jose M
author
Perez-Jimenez, Francisco
author
Perez-Martinez, Pablo
author
Lopez-Miranda, Jose
funder
Fundación Patrimonio Comunal Olivarero
funder
CITOLIVA: Centro Tecnológico del Olivar y del Aceite
funder
Regional Government of Andalusia (España)
funder
Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud
funder
Ministerio de Medio Ambiente, Medio Rural y Marino (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2017-10-30T13:32:25Z
2017-10-30T13:32:25Z
2016
PLoS One. 2016; 11(4):e0153096
10.1371/journal.pone.0153096
1932-6203
PLoS One
27064675
http://hdl.handle.net/20.500.12105/5238
Background: Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence of isolated overweight and obesity on carotid intima media thickness (IMT-CC), and also assessed whether this influence was determined by the presence of metabolic abnormalities. Methods: 1002 participants from the CordioPrev study were studied at entry. We determined their metabolic phenotypes and performed carotid ultrasound assessment. We evaluated the influence of obesity, overweight and metabolic phenotypes on the IMT-CC. Results: Metabolically sick participants (defined by the presence of two or more metabolic abnormalities) showed a greater IMT-CC than metabolically healthy individuals (p = 4 {*} 10(-6)). Overweight and normal weight patients who were metabolically healthy showed a lower IMT-CC than the metabolically abnormal groups (all p<0.05). When we evaluated only body weight (without considering metabolic phenotypes), overweight or obese patients did not differ significantly from normal-weight patients in their IMT-CC (p = 0.077). However, obesity was a determinant of IMT-CC when compared to the composite group of normal weight and overweight patients (all not obese). Conclusions: In coronary patients, a metabolically abnormal phenotype is associated with a greater IMT-CC, and may be linked to a higher risk of suffering new cardiovascular events. The protection conferred in the IMT-CC by the absence of metabolic abnormality may be blunted by the presence of obesity.
eng
INTIMA-MEDIA THICKNESS
AMERICAN-HEART-ASSOCIATION
CARDIOVASCULAR RISK-FACTORS
NORMAL-WEIGHT
INSULIN-RESISTANCE
ALL-CAUSE
HEALTHY
MORTALITY
EVENTS
INFLAMMATION
Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
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InfluenceOfObesityAndMetabolic_2016
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InfluenceOfObesityAndMetabolic_2016.txt