2026-07-22T05:26:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/52382024-09-27T08:29:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Talavera-Garcia, Eva author Delgado-Lista, Javier author García-Ríos, Antonio author Delgado-Casado, Nieves author Gomez-Luna, Purificacion author Gomez-Garduno, Angela author Gomez-Delgado, Francisco author Alcala-Diaz, Juan Francisco author Yubero-Serrano, Elena author Marin, Carmen author Perez-Caballero, Ana I. author Fuentes-Jimenez, Francisco J. author Camargo, Antonio author Rodriguez-Cantalejo, Fernando author Tinahones, Francisco J. author Ordovas, Jose M author Perez-Jimenez, Francisco author Perez-Martinez, Pablo author Lopez-Miranda, Jose author 2016 Background: Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence of isolated overweight and obesity on carotid intima media thickness (IMT-CC), and also assessed whether this influence was determined by the presence of metabolic abnormalities. Methods: 1002 participants from the CordioPrev study were studied at entry. We determined their metabolic phenotypes and performed carotid ultrasound assessment. We evaluated the influence of obesity, overweight and metabolic phenotypes on the IMT-CC. Results: Metabolically sick participants (defined by the presence of two or more metabolic abnormalities) showed a greater IMT-CC than metabolically healthy individuals (p = 4 {*} 10(-6)). Overweight and normal weight patients who were metabolically healthy showed a lower IMT-CC than the metabolically abnormal groups (all p<0.05). When we evaluated only body weight (without considering metabolic phenotypes), overweight or obese patients did not differ significantly from normal-weight patients in their IMT-CC (p = 0.077). However, obesity was a determinant of IMT-CC when compared to the composite group of normal weight and overweight patients (all not obese). Conclusions: In coronary patients, a metabolically abnormal phenotype is associated with a greater IMT-CC, and may be linked to a higher risk of suffering new cardiovascular events. The protection conferred in the IMT-CC by the absence of metabolic abnormality may be blunted by the presence of obesity. PLoS One. 2016; 11(4):e0153096 10.1371/journal.pone.0153096 1932-6203 PLoS One 27064675 http://hdl.handle.net/20.500.12105/5238 INTIMA-MEDIA THICKNESS AMERICAN-HEART-ASSOCIATION CARDIOVASCULAR RISK-FACTORS NORMAL-WEIGHT INSULIN-RESISTANCE ALL-CAUSE HEALTHY MORTALITY EVENTS INFLAMMATION Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)