2026-07-21T14:32:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52372024-10-31T11:49:53Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Scialo, Filippo
author
Sriram, Ashwin
author
Fernandez-Ayala, Daniel
author
Gubina, Nina
author
Lohmus, Madis
author
Nelson, Glyn
author
Logan, Angela
author
Cooper, Helen M.
author
Navas, Placido
author
Enriquez, Jose Antonio
author
Murphy, Michael P.
author
Sanz, Alberto
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Finlands Akademi (Finlandia)
funder
Biotechnology and Biological Sciences Research Council (Reino Unido)
funder
Centre for International Mobility (Finlandia)
funder
Medical Research Council (Reino Unido)
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
2017-10-30T13:32:25Z
2017-10-30T13:32:25Z
2016
Cell Metab. 2016; 23(4):725-34
10.1016/j.cmet.2016.03.009
1932-7420
1550-4131
Cell Metabolism
27076081
http://hdl.handle.net/20.500.12105/5237
Increased production of reactive oxygen species (ROS) has long been considered a cause of aging. However, recent studies have implicated ROS as essential secondary messengers. Here we show that the site of ROS production significantly contributes to their apparent dual nature. We report that ROS increase with age as mitochondrial function deteriorates. However, we also demonstrate that increasing ROS production specifically through respiratory complex I reverse electron transport extends Drosophila lifespan. Reverse electron transport rescued pathogenesis induced by severe oxidative stress, highlighting the importance of the site of ROS production in signaling. Furthermore, preventing ubiquinone reduction, through knockdown of PINK1, shortens lifespan and accelerates aging; phenotypes that are rescued by increasing reverse electron transport. These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging.
eng
INCREASING OXIDATIVE STRESS
CAENORHABDITIS-ELEGANS
DIETARY RESTRICTION
C. ELEGANS
EXPRESSION
LONGEVITY
CATALASE
MITOHORMESIS
RESPIRATION
INHIBITION
Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan
journal article
URL
https://repisalud.isciii.es/bitstreams/ab35a996-22ec-4242-b30d-9b509998ece1/download
File
MD5
1700d833dd23f6cf223ebf25ccb0b7ea
4064159
application/pdf
MitochondrialROSProducedVia_2016
URL
https://repisalud.isciii.es/bitstreams/d623222b-c1e3-4cdd-8dc1-eb7469c1af2d/download
File
MD5
650cdc105ba972ca81c12839e550a17b
2160665
application/pdf
MitochondrialROSProducedVia_2016_suppl1
URL
https://repisalud.isciii.es/bitstreams/1caf4e50-d718-4fb5-9d1c-58c907a5b905/download
File
MD5
9471fab0f5f3614f4c52b0796e0c881a
27256
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
MitochondrialROSProducedVia_2016_suppl2
URL
https://repisalud.isciii.es/bitstreams/b7cdd2d0-a21e-47e9-ac43-106cc863d4b1/download
File
MD5
e2f24a8f21dfaa49ed2a9827bc9663cc
38780
text/plain
MitochondrialROSProducedVia_2016.txt
URL
https://repisalud.isciii.es/bitstreams/51ee2110-4ae2-4a78-bba9-ce486f9f0956/download
File
MD5
22f426a4b10f8bc3a7dafdfdd6df6e9e
29662
text/plain
MitochondrialROSProducedVia_2016_suppl1.txt
URL
https://repisalud.isciii.es/bitstreams/82988d91-fc45-467b-8aa4-ec8f33696d0c/download
File
MD5
bb10bf36d5235bc74db4abf1a1749ed0
9733
text/plain
MitochondrialROSProducedVia_2016_suppl2.txt