2026-04-29T22:57:50Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/52292024-11-29T16:35:24Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_19605col_20.500.12105_19597
Repisalud author Fernandez-Alvira, Juan Miguel author Fuster, Valentin author Dorado, Beatriz author Soberon, Nora author Flores, Ignacio author Gallardo, Mercedes author Pocock, Stuart author Blasco, MA author Andres, Vicente funder Fundación ProCNIC funder Instituto de Salud Carlos III funder Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) funder Ministerio de Economía y Competitividad (España) funder Botín Foundation 2017-10-30T13:15:45Z 2017-10-30T13:15:45Z 2016 J Am Coll Cardiol. 2016; 67(21):2467-76 10.1016/j.jacc.2016.03.530 1558-3597 0735-1097 Journal of the American College of Cardiology 27230041 http://hdl.handle.net/20.500.12105/5229 BACKGROUND Leucocyte telomere length (LTL) shortening is associated with cardiovascular ischemic events and mortality in humans, but data on its association with subclinical atherosclerosis are scarce. Whether the incidence and severity of subclinical atherosclerosis are associated with the abundance of critically short telomeres, a major trigger of cellular senescence, remains unknown. OBJECTIVES The authors conducted a cross-sectional exploration of the association between subclinical atherosclerosis burden and both average LTL and the abundance of short telomeres (\% LTL<3 kb). METHODS Telomere length was assessed by high-throughput quantitative fluorescence in situ hybridization in circulating leukocytes from 1,459 volunteers without established cardiovascular disease (58\% men, 40 to 54 years of age) from the PESA (Progression of Early Subclinical Atherosclerosis) study. Subclinical atherosclerosis was evaluated by coronary artery calcium scan and 2-dimensional/3-dimensional ultrasound in different aortic territories. Statistical significance of differences among multiple covariates was assessed with linear regression models. Independent associations of telomere parameters with plaque presence were evaluated using general linear models. RESULTS In men and women, age was inversely associated with LTL (Pearson's r = -0.127, p < 0.001) and directly with \% LTL<3 kb (Pearson's r = 0.085; p = 0.001). Short LTL reached statistical significance as a determinant of total and femoral plaque in men, but not in women. However, this association was not sustained after adjustment for age or additional adjustment for cardiovascular risk factors. No significant independent association was found between \% LTL<3 kb and plaque burden. Serum-oxidized low-density lipoprotein levels were directly associated with \% LTL<3 kb in men (p = 0.008) and women (p < 0.001). CONCLUSIONS In a cross-sectional study of a middle-aged population, average LTL and short telomere load are not significant independent determinants of subclinical atherosclerosis. Longitudinal follow-up of PESA participants will assess long-term associations between telomere length and progression of subclinical atherosclerosis. eng Cardiovascular disease Leukocyte telomere length Short telomeres CORONARY-ARTERY CALCIFICATION CARDIOVASCULAR-DISEASE RISK GENERAL-POPULATION VASCULAR-DISEASE LIFE-SPAN ASSOCIATION METAANALYSIS SENESCENCE CELLS GRANULOCYTES Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis The PESA Study journal article URL https://repisalud.isciii.es/bitstreams/cba1c4bd-7d03-436d-a39e-f892df017a01/download File MD5 206b24e25856ec07d30926c353cb9bfb 1696625 application/pdf ShortTelomereLoadTelomere_2016.pdf URL https://repisalud.isciii.es/bitstreams/f8c7ea66-5d06-496f-bda9-1586e7323a77/download File MD5 6315cb5bee0d830464aba140c65346ec 45724 text/plain ShortTelomereLoadTelomere_2016.pdf.txt