2026-04-27T01:59:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52282024-09-27T08:53:01Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rodius, Sophie
author
Androsova, Ganna
author
Gotz, Lou
author
Liechti, Robin
author
Crespo, Isaac
author
Merz, Susanne
author
Nazarov, Petr V.
author
de Klein, Niek
author
Jeanty, Celine
author
Gonzalez-Rosa, Juan M.
author
Muller, Arnaud
author
Bernardin, Francois
author
Niclou, Simone P.
author
Vallar, Laurent
author
Mercader, Nadia
author
Ibberson, Mark
author
Xenarios, Ioannis
author
Azuaje, Francisco
funder
Luxembourg National Research Fund
funder
Swiss National Research Foundation
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2017-10-30T13:15:45Z
2017-10-30T13:15:45Z
2016
Sci Rep. 2016; 6:26822
2045-2322
http://hdl.handle.net/20.500.12105/5228
27241320
10.1038/srep26822
Scientific Reports
The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration.
eng
MYOCARDIAL-INFARCTION
GENE-EXPRESSION
CARDIAC REGENERATION
EPICARDIAL CELLS
INJURY
CARDIOMYOCYTES
MODEL
CRYOINJURY
TARGET
DIFFERENTIATION
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish
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