2026-05-22T17:28:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52182024-09-27T07:57:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Barreiro, Olga
author
Cibrian, Danay
author
Clemente, Cristina
author
Álvarez, David
author
Moreno, Vanessa
author
Valiente, Iñigo
author
Bernad, Antonio
author
Vestweber, Dietmar
author
Arroyo, Alicia G
author
Martin, Pilar
author
von Andrian, Ulrich H.
author
Sanchez Madrid, Francisco
funder
Fundación Alfonso Martín Escudero
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
National Institutes of Health (Estados Unidos)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
2017-10-30T13:15:44Z
2017-10-30T13:15:44Z
2016
10.7554/eLife.15251
2050-084X
ELIFE
27304075
http://hdl.handle.net/20.500.12105/5218
Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.
eng
CD103(+) DENDRITIC CELLS
RESIDENT MACROPHAGES
IN-VIVO
ACTIVATED MACROPHAGES
EXPRESSION PROFILES
BLOOD-VESSELS
KUPFFER CELLS
LYMPH-NODES
STEM-CELLS
RNA-SEQ
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair
journal article
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PivotalRoleForSkinTransendothelial_2016
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PivotalRoleForSkinTransendothelial_2016_Fig
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PivotalRoleForSkinTransendothelial_2016.txt
URL
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PivotalRoleForSkinTransendothelial_2016_Fig.txt