2026-07-23T20:21:49Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/52182024-09-27T07:57:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Barreiro, Olga author Cibrian, Danay author Clemente, Cristina author Álvarez, David author Moreno, Vanessa author Valiente, Iñigo author Bernad, Antonio author Vestweber, Dietmar author Arroyo, Alicia G author Martin, Pilar author von Andrian, Ulrich H. author Sanchez Madrid, Francisco author 2016 Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis. 10.7554/eLife.15251 2050-084X ELIFE 27304075 http://hdl.handle.net/20.500.12105/5218 CD103(+) DENDRITIC CELLS RESIDENT MACROPHAGES IN-VIVO ACTIVATED MACROPHAGES EXPRESSION PROFILES BLOOD-VESSELS KUPFFER CELLS LYMPH-NODES STEM-CELLS RNA-SEQ Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair