2026-08-29T14:04:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52162024-09-27T08:23:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Andres-Delgado, Laura
author
Mercader, Nadia
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea. Comisión Europea
funder
Fundación ProCNIC
2017-10-30T13:15:42Z
2017-10-30T13:15:42Z
2016
Biochim Biophys Acta. 2016; 1863(7 Pt B):1707-1716
10.1016/j.bbamcr.2016.03.004
0006-3002
0167-4889
Biochimica et Biophysica Acta-Molecular Cell Research
26952935
http://hdl.handle.net/20.500.12105/5216
Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. (c) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
eng
Cardiac development
Blood and pericardial flow
Mechanosensing
Mechanotransduction
Zebrafish
Mouse
LEFT-RIGHT ASYMMETRY
ARTERIAL-VENOUS DIFFERENTIATION
ENDOTHELIN-CONVERTING ENZYME-1
PROEPICARDIAL CELL-MIGRATION
NITRIC-OXIDE SYNTHASE
CARDIOMYOCYTE PROLIFERATION
VASCULAR DEVELOPMENT
EMBRYONIC HEART
ZEBRAFISH HEART
SHEAR-STRESS
Interplay between cardiac function and heart development
journal article
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InterplayBetweenCardiacFunction_2016
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text/plain
InterplayBetweenCardiacFunction_2016.txt