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oai:repisalud.isciii.es:20.500.12105/52162024-09-27T08:23:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Andres-Delgado, Laura author Mercader, Nadia author 2016 Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. (c) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license Biochim Biophys Acta. 2016; 1863(7 Pt B):1707-1716 10.1016/j.bbamcr.2016.03.004 0006-3002 0167-4889 Biochimica et Biophysica Acta-Molecular Cell Research 26952935 http://hdl.handle.net/20.500.12105/5216 Cardiac development Blood and pericardial flow Mechanosensing Mechanotransduction Zebrafish Mouse LEFT-RIGHT ASYMMETRY ARTERIAL-VENOUS DIFFERENTIATION ENDOTHELIN-CONVERTING ENZYME-1 PROEPICARDIAL CELL-MIGRATION NITRIC-OXIDE SYNTHASE CARDIOMYOCYTE PROLIFERATION VASCULAR DEVELOPMENT EMBRYONIC HEART ZEBRAFISH HEART SHEAR-STRESS Interplay between cardiac function and heart development