2026-04-29T16:05:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/52072024-09-27T10:02:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Barragan, Rocio
author
Coltell, Oscar
author
Asensio, Eva M.
author
Frances, Francesc
author
Sorli, Jose V.
author
Estruch, Ramon
author
Salas-Huetos, Albert
author
Ordovas, Jose M
author
Corella, Dolores
funder
Jaume I University (España)
funder
Ministerio de Economía y Competitividad (España)
funder
United States Department of Agriculture. National Institute of Food and Agriculture
funder
Generalitat Valenciana (España)
funder
Complutense University of Madrid (España)
funder
Harvard University (Estados Unidos)
2017-10-30T13:15:40Z
2017-10-30T13:15:40Z
2016
Int J Mol Sci. 2016; 17(8):E1338
10.3390/ijms17081338
1422-0067
International Journal of Molecular Sciences
27537871
http://hdl.handle.net/20.500.12105/5207
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvencion con DIeta MEDiterranea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 +/- 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 +/- 0.4 in AA, 5.9 +/- 0.5 in AG and 9.1 +/- 1.8 g/day in GG; p(adjusted) = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (> 2 drinks/day in men and > 1 in women): 5.9\% in AA versus 17.5\% in GG; p(adjusted) < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.
eng
MicroRNAs
Alcohol
miR27a
Mediterranean
SINGLE NUCLEOTIDE POLYMORPHISMS
GASTRIC-CANCER SUSCEPTIBILITY
FUNCTIONAL POLYMORPHISM
MENDELIAN RANDOMIZATION
CHINESE POPULATION
COLORECTAL-CANCER
GENETIC VARIANT
HEART-DISEASE
USE DISORDERS
RISK
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
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MicroRNAsAndDrinkingAssociationBetween_2016.txt