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oai:repisalud.isciii.es:20.500.12105/52072024-09-27T10:02:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Barragan, Rocio author Coltell, Oscar author Asensio, Eva M. author Frances, Francesc author Sorli, Jose V. author Estruch, Ramon author Salas-Huetos, Albert author Ordovas, Jose M author Corella, Dolores author 2016 Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvencion con DIeta MEDiterranea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 +/- 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 +/- 0.4 in AA, 5.9 +/- 0.5 in AG and 9.1 +/- 1.8 g/day in GG; p(adjusted) = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (> 2 drinks/day in men and > 1 in women): 5.9\% in AA versus 17.5\% in GG; p(adjusted) < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption. Int J Mol Sci. 2016; 17(8):E1338 10.3390/ijms17081338 1422-0067 International Journal of Molecular Sciences 27537871 http://hdl.handle.net/20.500.12105/5207 MicroRNAs Alcohol miR27a Mediterranean SINGLE NUCLEOTIDE POLYMORPHISMS GASTRIC-CANCER SUSCEPTIBILITY FUNCTIONAL POLYMORPHISM MENDELIAN RANDOMIZATION CHINESE POPULATION COLORECTAL-CANCER GENETIC VARIANT HEART-DISEASE USE DISORDERS RISK MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population