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oai:repisalud.isciii.es:20.500.12105/52042024-09-27T08:08:43Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Peñalvo, Jose L author Fernandez-Friera, Leticia author Lopez-Melgar, Beatriz author Uzhova, Irina author Oliva, Belen author Fernandez-Alvira, Juan Miguel author Laclaustra, Martin author Pocock, Stuart author Mocoroa, Agustin author Mendiguren, Jose M author Sanz, Gines author Guallar, Eliseo author Bansilal, Sameer author Vedanthan, Rajesh author Jimenez-Borreguero, Luis J. author Ibáñez, Borja author Ordovas, Jose M author Fernandez-Ortiz, Antonio author Bueno, Hector author Fuster, Valentin author 2016 BACKGROUND The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. OBJECTIVES This study sought to quantify the association between specific dietary patterns and presence and extent of subclinical atherosclerosis in a population of asymptomatic middle-aged adults. METHODS The PESA (Progression of Early Subclinical Atherosclerosis) study enrolled 4,082 asymptomatic participants 40 to 54 years of age (mean age 45.8 years; 63\% male) to evaluate the presence of subclinical atherosclerosis in multiple vascular territories. A fundamental objective of this cohort study was to evaluate the life-style-related determinants, including diet, on atherosclerosis onset and development. We conducted a cross-sectional analysis of baseline data, including detailed information on dietary habits obtained as part of the overall life-style and risk factor assessment, as well as a complete vascular imaging study that was performed blinded to the clinical information. RESULTS Most PESA participants follow a Mediterranean (40\% of participants) or a Western (41\%) dietary pattern. A new pattern, identified among 19\% of participants, was labeled as a social-business eating pattern, characterized by a high consumption of red meat, pre-made foods, snacks, alcohol, and sugar-sweetened beverages and frequent eating-out behavior. Participants following this pattern presented a significantly worse cardiovascular risk profile and, after adjustment for risk factors, increased odds of presenting subclinical atherosclerosis (odds ratio: 1.31; 95\% confidence interval: 1.06 to 1.63) compared with participants following a Mediterranean diet. CONCLUSIONS A new social-business eating pattern, characterized by high consumption of red and processed meat, alcohol, and sugar-sweetened beverages, and by frequent snacking and eating out as part of an overall unhealthy life-style, is associated with an increased prevalence, burden, and multisite presence of subclinical atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318) (C) 2016 by the American College of Cardiology Foundation. J Am Coll Cardiol. 2016; 68(8):805-14 10.1016/j.jacc.2016.05.080 1558-3597 0735-1097 Journal of the American College of Cardiology 27539172 http://hdl.handle.net/20.500.12105/5204 Cardiovascular disease Dietary patterns Plaque Subclinical atherosclerosis INTIMA-MEDIA THICKNESS MAJOR DIETARY PATTERNS CARDIOVASCULAR-DISEASE SUBCLINICAL ATHEROSCLEROSIS MEDITERRANEAN DIET RISK CORONARY COHORT METAANALYSIS PROGRESSION Association Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis