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00925njm 22002777a 4500 dc Pozo, Eduardo author Agudo-Quilez, Pilar author Rojas-Gonzalez, Antonio author Alvarado, Teresa author Olivera, Maria Jose author Jimenez-Borreguero, Luis J. author Alfonso, Fernando author 2016 Myocardial infarction and sudden cardiac death are frequently the first manifestation of coronary artery disease. For this reason, screening of asymptomatic coronary atherosclerosis has become an attractive field of research in cardiovascular medicine. Necropsy studies have described histopathological changes associated with the development of acute coronary events. In this regard, thin-cap fibroatheroma has been identified as the main vulnerable coronary plaque feature. Hence, many imaging techniques, such as coronary computed tomography, cardiac magnetic resonance or positron emission tomography, have tried to detect noninvasively these histomorphological characteristics with different approaches. In this article, we review the role of these diagnostic tools in the detection of vulnerable coronary plaque with particular interest in their advantages and limitations as well as the clinical implications of the derived findings. World J Cardiol. 2016; 8(9):520-533 10.4330/wjc.v8.i9.520 1949-8462 World Journal of Cardiology 27721935 http://hdl.handle.net/20.500.12105/5202 Atherosclerosis Vulnerable coronary plaque Diagnosis Cardiac computed tomography Cardiac magnetic resonance COMPUTED TOMOGRAPHIC ANGIOGRAPHY CARDIOVASCULAR-MAGNETIC-RESONANCE ACUTE MYOCARDIAL-INFARCTION NAVIGATED IMAGE-RECONSTRUCTION OPTICAL COHERENCE TOMOGRAPHY NAPKIN-RING SIGN INTRAVASCULAR ULTRASOUND CT ANGIOGRAPHY CONTRAST AGENT ATHEROSCLEROTIC PLAQUES Noninvasive diagnosis of vulnerable coronary plaque