2026-08-29T14:55:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51852024-09-27T08:08:32Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Del Toro, Raquel
author
Chevre, Raphael
author
Rodriguez, Cristina
author
Ordonez, Antonio
author
Martinez-Gonzalez, Jose
author
Andres, Vicente
author
Mendez-Ferrer, Simon
funder
Fundación ProCNIC
funder
Ministerio de Economía y Competitividad (España)
funder
Wellcome Trust
funder
MRC Cambridge Stem Cell Institute
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea
funder
Howard Hughes Medical Institute
funder
NHS - Blood and Transplant (NHSBT) (Reino Unido)
2017-10-20T10:33:52Z
2017-10-20T10:33:52Z
2016
Nat Commun. 2016; 7:12706
10.1038/ncomms12706
2041-1723
Nature Communications
27586429
http://hdl.handle.net/20.500.12105/5185
Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase similar to 30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only-increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis.
eng
MYELOID CALCIFYING CELLS
SMOOTH-MUSCLE-CELLS
PROGENITOR CELLS
VASA-VASORUM
STEM-CELLS
HEMATOPOIETIC STEM
MONOCYTE RECRUITMENT
NEOINTIMA FORMATION
ENDOTHELIAL-CELLS
MESENCHYMAL STEM
Nestin(+) cells direct inflammatory cell migration in atherosclerosis
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Nestin+CellsDirectInflammatory_2016.txt
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Nestin+CellsDirectInflammatory_2016.txt