2026-04-29T04:08:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51832024-09-27T07:56:41Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Soro-Arnaiz, Ines
author
Yang Li, Qilong Oscar
author
Torres-Capelli, Mar
author
Melendez-Rodriguez, Florinda
author
Veiga, Sonia
author
Veys, Koen
author
Sebastian, David
author
Elorza, Ainara
author
Tello, Daniel
author
Hernansanz-Agustin, Pablo
author
Cogliati, Sara
author
Moreno-Navarrete, Jose Maria
author
Balsa, Eduardo
author
Fuertes, Esther
author
Romanos, Eduardo
author
Martinez-Ruiz, Antonio
author
Enriquez, Jose Antonio
author
Fernandez-Real, Jose Manuel
author
Zorzano, Antonio
author
De Bock, Katrien
author
Aragones, Julian
funder
Ministerio de Educación y Ciencia (España)
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea
2017-10-20T10:33:52Z
2017-10-20T10:33:52Z
2016
Cell Rep. 2016; 16(11):2991-3002
2211-1247
http://hdl.handle.net/20.500.12105/5183
27626667
10.1016/j.celrep.2016.08.041
Cell Reports
Aging is associated with progressive white adipose tissue (WAT) enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV) activity and assembly are already repressed in white adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV components such as COX5B. At the molecular level, HIF1A binds to the Cox5b proximal promoter and represses its expression. Silencing of Cox5b decreased fatty acid oxidation and promoted intracellular lipid accumulation. Moreover, local in vivo Cox5b silencing in WAT of young mice increased the size of adipocytes, whereas restoration of COX5B expression in aging mice counteracted adipocyte enlargement. An age-dependent reduction in COX5B gene expression was also found in human visceral adipose tissue. Collectively, our findings establish a pivotal role for CIV dysfunction in progressive white adipocyte enlargement during aging, which can be restored to alleviate age-dependent WAT expansion.
eng
WHITE ADIPOSE-TISSUE
CYTOCHROME-C-OXIDASE
DIET-FED MICE
INSULIN-RESISTANCE
FAT
HYPOXIA
ADIPOCYTES
DYSFUNCTION
INFLAMMATION
GLUCOSE
Role of Mitochondrial Complex IV in Age-Dependent Obesity
journal article
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RoleOfMitochondrialComplex_2016
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RoleOfMitochondrialComplex_2016_suppl
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RoleOfMitochondrialComplex_2016.txt
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RoleOfMitochondrialComplex_2016_suppl.txt
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