2026-04-27T01:59:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51712024-09-27T10:13:36Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Chamorro, Virginia
author
Pandolfi, Rachele
author
Moreno, Laura
author
Barreira, Bianca
author
Martinez-Ramas, Andrea
author
Morales-Cano, Daniel
author
Ruiz-Cabello, Jesus
author
Angel Lorente, Jose
author
Duarte, Juan
author
Cogolludo, Angel
author
Luis Alvarez-Sala, Jose
author
Perez-Vizcaino, Francisco
funder
Fundación Mutua Madrileña
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
2017-10-20T10:33:51Z
2017-10-20T10:33:51Z
2016
Molecules. 2016; 21(12):E1739
1420-3049
http://hdl.handle.net/20.500.12105/5171
27999410
10.3390/molecules21121739
Molecules
Background: We hypothesized that treatment with quercetin could result in improved hemodynamics, lung inflammatory parameters and mortality in a rat model of hemorrhagic shock. Methods: Rats were anesthetized (80 mg/kg ketamine plus 8 mg/kg xylazine i.p.). The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg/kg) or vehicle were administered during resuscitation. Results: There was a trend for increased survival 84.6\% (11/13) in the treated group vs. the shock group 68.4\% (13/19, p > 0.05 Kaplan-Meier). Quercetin fully prevented the development of lung edema. The activity of aSMase was increased in the shock group compared to the sham group and the quercetin prevented this effect. However, other inflammatory markers such as myeloperoxidase activity, interleukin-6 in plasma or bronchoalveolar fluid were similar in the sham and shock groups. We found no bacterial DNA in plasma in these animals. Conclusions: Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion.
eng
Systemic arterial pressure
Lung edema
Hemorrhage
Trauma
Reperfusion
ACID SPHINGOMYELINASE
FLAVONOID QUERCETIN
IMPROVES SURVIVAL
OXIDATIVE STRESS
INJURY
GUT
SPHINGOLIPIDS
CERAMIDE
Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion
journal article
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688475
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EffectsOfQuercetinIn_2016
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afb1c5fa32963111572191966665ff5c
46557
text/plain
EffectsOfQuercetinIn_2016.txt