2026-06-14T13:00:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51692024-09-27T09:30:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Glytsou, Christina
author
Calvo, Enrique
author
Cogliati, Sara
author
Mehrotra, Arpit
author
Anastasia, Irene
author
Rigoni, Giovanni
author
Raimondi, Andrea
author
Shintani, Norihito
author
Loureiro, Marta
author
Vazquez, Jesus
author
Pellegrini, Luca
author
Enriquez, Jose Antonio
author
Scorrano, Luca
author
Soriano, Maria Eugenia
funder
Telethon Foundation (Italia)
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministero dell Istruzione, dell Universita e della Ricerca (Italia)
funder
Ministero della Salute (Italia)
funder
University of Padua (Italia)
2017-10-20T10:33:50Z
2017-10-20T10:33:50Z
2016
Cell Rep. 2016; 17(11):3024-3034
10.1016/j.celrep.2016.11.049
2211-1247
Cell Reports
27974214
http://hdl.handle.net/20.500.12105/5169
The mitochondrial contact site and cristae organizing system (MICOS) and Optic atrophy 1 (OPA1) control cristae shape, thus affecting mitochondrial function and apoptosis. Whether and how they physically and functionally interact is unclear. Here, we provide evidence that OPA1 is epistatic to MICOS in the regulation of cristae shape. Proteomic analysis identifies multiple MICOS components in native OPA1-containing high molecular weight complexes disrupted during cristae remodeling. MIC60, a core MICOS protein, physically interacts with OPA1, and together, they control cristae junction number and stability, OPA1 being epistatic to MIC60. OPA1 defines cristae width and junction diameter independently of MIC60. Our combination of proteomics, biochemistry, genetics, and electron tomography provides a unifying model for mammalian cristae biogenesis by OPA1 and MICOS.
eng
CYTOCHROME-C RELEASE
CONTACT SITE
ORGANIZING SYSTEM
MITOFILIN COMPLEXES
APOPTOSIS
MEMBRANE
OPA1
ORGANIZATION
PATHWAY
FUSION
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control
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OpticAtrophy1IsEpistatic_2016
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OpticAtrophy1IsEpistatic_2016.txt
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OpticAtrophy1IsEpistatic_2016.txt