2026-06-14T03:44:21Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/51672024-09-27T10:08:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607

00925njm 22002777a 4500 dc Velasco, Carlos author Mateo, Jesus author Santos, Arnoldo author Mota-Cobian, Adriana author Herranz, Fernando author Pellico, Juan author Mota, Ruben A. author Espana, Samuel author Ruiz-Cabello, Jesus author 2017 Background: In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of Ga-68-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal. Each radiotracer injection was performed simultaneously to the injection of fluorescent microspheres. PBF images were generated applying a two-compartment exchange model over the dynamic PET images. PET and microspheres values were compared by regression analysis and Bland-Altman plot. Results: The capability of the proposed technique to produce 3D regional PBF images was demonstrated. The correlation evaluation between Ga-68-DOTA PET and microspheres showed a good and significant correlation (r = 0.74, P < 0.001). Conclusions: Assessment of PBF with the proposed technique allows combining the high quantitative accuracy of PET imaging with the use of Ga-68/Ge-68 generators. Thus, Ga-68-DOTA PET emerges as a potential inexpensive method for measuring PBF in clinical settings with an extended use. EJNMMI Res. 2017; 7(1):7 10.1186/s13550-017-0259-2 2191-219X EJNMMI Research 28101850 http://hdl.handle.net/20.500.12105/5167 PET Pulmonary blood flow Gallium-68 Fluorescent microspheres POSITRON-EMISSION-TOMOGRAPHY MYOCARDIAL-PERFUSION LUNG PERFUSION PIG MODEL QUANTIFICATION MICROSPHERES VALIDATION CT DEPOSITION VOLUME Assessment of regional pulmonary blood flow using Ga-68-DOTA PET