2026-08-12T20:37:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51652024-09-27T07:55:52Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sanchez-Aguilera, Abel
author
Mendez-Ferrer, Simon
funder
Wellcome Trust
funder
Medical Research Council (Reino Unido)
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación ProCNIC
funder
RETICS-Terapia Celular (TERCEL-ISCIII) (España)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea
funder
European Hematology Association
funder
Howard Hughes Medical Institute
2017-10-20T10:33:50Z
2017-10-20T10:33:50Z
2017
Cell Mol Life Sci. 2017; 74(4):579-590
10.1007/s00018-016-2306-y
1420-9071
1420-682X
Cellular and Molecular Life Sciences
27436341
http://hdl.handle.net/20.500.12105/5165
Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with and are modulated by a complex multicellular microenvironment in the bone marrow, which includes both the HSC progeny and multiple non-hematopoietic cell types. Intense work is gradually throwing light on the composition of the HSC niche and the molecular cues exchanged between its components, which has implications for HSC production, maintenance and expansion. In addition, it has become apparent that bidirectional interactions between leukemic cells and their niche play a previously unrecognized role in the initiation and development of hematological malignancies. Consequently, targeting of the malignant niche holds considerable promise for more specific antileukemic therapies. Here we summarize the latest insights into HSC niche biology and recent work showing multiple connections between hematological malignancy and alterations in the bone marrow microenvironment.
eng
Hematopoietic stem cell
Stem cell niche
Bone marrow microenvironment
Leukemia
Leukemia stem cell
BONE-MARROW NICHE
CHRONIC MYELOGENOUS LEUKEMIA
MESENCHYMAL STROMAL CELLS
ACUTE MYELOID-LEUKEMIA
IN-VIVO
PROGENITOR CELLS
ENDOTHELIAL NICHES
SELF-RENEWAL
MOUSE MODEL
MICROENVIRONMENT
The hematopoietic stem-cell niche in health and leukemia
journal article
URL
https://repisalud.isciii.es/bitstreams/d44009a4-835f-4dad-942d-e2c69aca4af3/download
File
MD5
453f0535a1c35019969af26cc6ac4f9e
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application/pdf
HematopoieticStemCellNiche_2017
URL
https://repisalud.isciii.es/bitstreams/ea66c495-7371-4273-a48c-6243ecc8e227/download
File
MD5
8723f21cca1ed555faca51f3c8209f0c
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text/plain
HematopoieticStemCellNiche_2017.txt