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oai:repisalud.isciii.es:20.500.12105/51652024-09-27T07:55:52Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Sanchez-Aguilera, Abel author Mendez-Ferrer, Simon author 2017 Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with and are modulated by a complex multicellular microenvironment in the bone marrow, which includes both the HSC progeny and multiple non-hematopoietic cell types. Intense work is gradually throwing light on the composition of the HSC niche and the molecular cues exchanged between its components, which has implications for HSC production, maintenance and expansion. In addition, it has become apparent that bidirectional interactions between leukemic cells and their niche play a previously unrecognized role in the initiation and development of hematological malignancies. Consequently, targeting of the malignant niche holds considerable promise for more specific antileukemic therapies. Here we summarize the latest insights into HSC niche biology and recent work showing multiple connections between hematological malignancy and alterations in the bone marrow microenvironment. Cell Mol Life Sci. 2017; 74(4):579-590 10.1007/s00018-016-2306-y 1420-9071 1420-682X Cellular and Molecular Life Sciences 27436341 http://hdl.handle.net/20.500.12105/5165 Hematopoietic stem cell Stem cell niche Bone marrow microenvironment Leukemia Leukemia stem cell BONE-MARROW NICHE CHRONIC MYELOGENOUS LEUKEMIA MESENCHYMAL STROMAL CELLS ACUTE MYELOID-LEUKEMIA IN-VIVO PROGENITOR CELLS ENDOTHELIAL NICHES SELF-RENEWAL MOUSE MODEL MICROENVIRONMENT The hematopoietic stem-cell niche in health and leukemia